Gene basic information
| LiverAtlas Gene ID |
HuLG003888 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PTGS2 |
|
Synonyms |
COXN2|COX2|GRIPGHS|PGG/HS|PGHSN2|PHSN2|hCoxN2 |
|
Gene name |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
|
Gene Type |
protein-coding |
|
Chromosome |
1 |
|
Genomics Location |
1q25.2-q25.3 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:9605
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001516 |
prostaglandin biosynthetic process |
|
GO:0004601 |
peroxidase activity |
|
GO:0004666 |
prostaglandin-endoperoxide synthase activity |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005788 |
endoplasmic reticulum lumen |
|
GO:0005789 |
endoplasmic reticulum membrane |
|
GO:0005792 |
microsome |
|
GO:0005901 |
caveola |
|
GO:0006633 |
fatty acid biosynthetic process |
|
GO:0006692 |
prostanoid metabolic process |
|
GO:0006693 |
prostaglandin metabolic process |
|
GO:0006805 |
xenobiotic metabolic process |
|
GO:0006928 |
cellular component movement |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007566 |
embryo implantation |
|
GO:0007613 |
memory |
|
GO:0008217 |
regulation of blood pressure |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008289 |
lipid binding |
|
GO:0009750 |
response to fructose stimulus |
|
GO:0010042 |
response to manganese ion |
|
GO:0010243 |
response to organic nitrogen |
|
GO:0010575 |
positive regulation vascular endothelial growth factor production |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0016020 |
membrane |
|
GO:0016491 |
oxidoreductase activity |
|
GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
|
GO:0019371 |
cyclooxygenase pathway |
|
GO:0019899 |
enzyme binding |
|
GO:0020037 |
heme binding |
|
GO:0030282 |
bone mineralization |
|
GO:0030728 |
ovulation |
|
GO:0031394 |
positive regulation of prostaglandin biosynthetic process |
|
GO:0031622 |
positive regulation of fever generation |
|
GO:0031915 |
positive regulation of synaptic plasticity |
|
GO:0032227 |
negative regulation of synaptic transmission, dopaminergic |
|
GO:0032355 |
response to estradiol stimulus |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0033280 |
response to vitamin D |
|
GO:0034097 |
response to cytokine stimulus |
|
GO:0042446 |
hormone biosynthetic process |
|
GO:0042493 |
response to drug |
|
GO:0042640 |
anagen |
|
GO:0043005 |
neuron projection |
|
GO:0043065 |
positive regulation of apoptosis |
|
GO:0043234 |
protein complex |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045907 |
positive regulation of vasoconstriction |
|
GO:0045987 |
positive regulation of smooth muscle contraction |
|
GO:0046697 |
decidualization |
|
GO:0046872 |
metal ion binding |
|
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
|
GO:0050727 |
regulation of inflammatory response |
|
GO:0051384 |
response to glucocorticoid stimulus |
|
GO:0051726 |
regulation of cell cycle |
|
GO:0051926 |
negative regulation of calcium ion transport |
|
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
|
GO:0071636 |
positive regulation of transforming growth factor-beta production |
|
GO:0090050 |
positive regulation of cell migration involved in sprouting angiogenesis |
|
GO:0090271 |
positive regulation of fibroblast growth factor production |
|
GO:0090336 |
positive regulation of brown fat cell differentiation |
|
GO:0090362 |
positive regulation of platelet-derived growth factor production |
