Gene basic information
| LiverAtlas Gene ID |
HuLG003892 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PTK2 |
|
Synonyms |
FADK|FAK|FAK1|FRNK|pp125FAK |
|
Gene name |
PTK2 protein tyrosine kinase 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
8 |
|
Genomics Location |
8q24.3 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ61553, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2) PTK2 protein tyrosine kinase 2 isoform b variant |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:9611
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0004672 |
protein kinase activity |
|
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
|
GO:0004871 |
signal transducer activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005856 |
cytoskeleton |
|
GO:0005886 |
plasma membrane |
|
GO:0005925 |
focal adhesion |
|
GO:0006915 |
apoptosis |
|
GO:0006921 |
cellular component disassembly involved in apoptosis |
|
GO:0007172 |
signal complex assembly |
|
GO:0007229 |
integrin-mediated signaling pathway |
|
GO:0007411 |
axon guidance |
|
GO:0007596 |
blood coagulation |
|
GO:0008432 |
JUN kinase binding |
|
GO:0018108 |
peptidyl-tyrosine phosphorylation |
|
GO:0030054 |
cell junction |
|
GO:0033628 |
regulation of cell adhesion mediated by integrin |
|
GO:0042169 |
SH2 domain binding |
|
GO:0046777 |
protein autophosphorylation |
|
GO:0048013 |
ephrin receptor signaling pathway |
|
GO:0060396 |
growth hormone receptor signaling pathway |
