Gene basic information
| LiverAtlas Gene ID |
HuLG004016 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
RB1 |
|
Synonyms |
OSRC|RB|p105NRb|pRb|pp110 |
|
Gene name |
retinoblastoma 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
13 |
|
Genomics Location |
13q14.2 |
|
Known cancer genes |
Yes |
|
Protein products |
Retinoblastoma susceptibility protein Retinoblastoma suspectibility protein Retinoblastoma suspectibility protein Retinoblastoma suspectibility protein Retinoblastoma susceptibility protein |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:9884
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000080 |
G1 phase of mitotic cell cycle |
|
GO:0000082 |
G1/S transition of mitotic cell cycle |
|
GO:0000083 |
regulation of transcription involved in G1/S phase of mitotic cell cycle |
|
GO:0000084 |
S phase of mitotic cell cycle |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0000278 |
mitotic cell cycle |
|
GO:0000279 |
M phase |
|
GO:0000785 |
chromatin |
|
GO:0003677 |
DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0003713 |
transcription coactivator activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005819 |
spindle |
|
GO:0006338 |
chromatin remodeling |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0006469 |
negative regulation of protein kinase activity |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0007346 |
regulation of mitotic cell cycle |
|
GO:0008134 |
transcription factor binding |
|
GO:0016514 |
SWI/SNF complex |
|
GO:0016605 |
PML body |
|
GO:0019900 |
kinase binding |
|
GO:0030182 |
neuron differentiation |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030521 |
androgen receptor signaling pathway |
|
GO:0031134 |
sister chromatid biorientation |
|
GO:0031175 |
neuron projection development |
|
GO:0031575 |
mitotic cell cycle G1/S transition checkpoint |
|
GO:0031625 |
ubiquitin protein ligase binding |
|
GO:0034088 |
maintenance of mitotic sister chromatid cohesion |
|
GO:0035189 |
Rb-E2F complex |
|
GO:0042551 |
neuron maturation |
|
GO:0043353 |
enucleate erythrocyte differentiation |
|
GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0043550 |
regulation of lipid kinase activity |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045445 |
myoblast differentiation |
|
GO:0045651 |
positive regulation of macrophage differentiation |
|
GO:0045749 |
negative regulation of S phase of mitotic cell cycle |
|
GO:0045842 |
positive regulation of mitotic metaphase/anaphase transition |
|
GO:0045879 |
negative regulation of smoothened signaling pathway |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0048565 |
digestive tract development |
|
GO:0048667 |
cell morphogenesis involved in neuron differentiation |
|
GO:0050680 |
negative regulation of epithelial cell proliferation |
|
GO:0050681 |
androgen receptor binding |
|
GO:0051146 |
striated muscle cell differentiation |
|
GO:0051219 |
phosphoprotein binding |
|
GO:0051301 |
cell division |
|
GO:0051318 |
G1 phase |
|
GO:0051402 |
neuron apoptosis |
|
GO:0071459 |
protein localization to chromosome, centromeric region |
|
GO:0071922 |
regulation of cohesin localization to chromatin |
|
GO:0090230 |
regulation of centromere complex assembly |
