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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG004048

Entrez Gene ID

5970

Official Gene Symbol

RELA

Synonyms

MGC131774|NFKB3|p65

Gene name

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Gene Type

protein-coding

Chromosome

11

Genomics Location

11q13

Known cancer genes

Yes

Protein products

Uncharacterized protein

Protein p65

RELA protein

Transcription factor p65

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatocellular carcinoma

Database cross reference

HGNC:9955
MIM:164014
Ensembl:ENSG00000173039
HPRD:01241
RefSeq Genomic nucleotide accession:AC_000054
RefSeq Genomic nucleotide gi:89161188

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001889

liver development

GO:0001942

hair follicle development

GO:0002224

toll-like receptor signaling pathway

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO:0002756

MyD88-independent toll-like receptor signaling pathway

GO:0003677

DNA binding

GO:0003682

chromatin binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005667

transcription factor complex

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006351

transcription, DNA-dependent

GO:0006916

anti-apoptosis

GO:0006954

inflammatory response

GO:0006968

cellular defense response

GO:0007568

aging

GO:0008063

Toll signaling pathway

GO:0008134

transcription factor binding

GO:0008284

positive regulation of cell proliferation

GO:0009612

response to mechanical stimulus

GO:0009617

response to bacterium

GO:0009887

organ morphogenesis

GO:0010033

response to organic substance

GO:0010035

response to inorganic substance

GO:0010224

response to UV-B

GO:0014040

positive regulation of Schwann cell differentiation

GO:0014070

response to organic cyclic compound

GO:0019221

cytokine-mediated signaling pathway

GO:0019901

protein kinase binding

GO:0031293

membrane protein intracellular domain proteolysis

GO:0031625

ubiquitin protein ligase binding

GO:0032332

positive regulation of chondrocyte differentiation

GO:0032403

protein complex binding

GO:0032495

response to muramyl dipeptide

GO:0032496

response to lipopolysaccharide

GO:0032570

response to progesterone stimulus

GO:0032868

response to insulin stimulus

GO:0033590

response to cobalamin

GO:0033613

activating transcription factor binding

GO:0034130

toll-like receptor 1 signaling pathway

GO:0034134

toll-like receptor 2 signaling pathway

GO:0034138

toll-like receptor 3 signaling pathway

GO:0034142

toll-like receptor 4 signaling pathway

GO:0042177

negative regulation of protein catabolic process

GO:0042301

phosphate binding

GO:0042493

response to drug

GO:0042542

response to hydrogen peroxide

GO:0042802

identical protein binding

GO:0043066

negative regulation of apoptosis

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

GO:0043200

response to amino acid stimulus

GO:0043278

response to morphine

GO:0043565

sequence-specific DNA binding

GO:0044419

interspecies interaction between organisms

GO:0045084

positive regulation of interleukin-12 biosynthetic process

GO:0045087

innate immune response

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046627

negative regulation of insulin receptor signaling pathway

GO:0047485

protein N-terminus binding

GO:0048011

nerve growth factor receptor signaling pathway

GO:0050727

regulation of inflammatory response

GO:0050852

T cell receptor signaling pathway

GO:0051059

NF-kappaB binding

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051591

response to cAMP

GO:0051607

defense response to virus

GO:0070431

nucleotide-binding oligomerization domain containing 2 signaling pathway

GO:0070491

repressing transcription factor binding

GO:0070555

response to interleukin-1

GO:0071532

ankyrin repeat binding