HuLG004224

Entrez Gene ID

6256

Official Gene Symbol

RXRA

Synonyms

FLJ00280|FLJ00318|FLJ16020|FLJ16733|MGC102720|NR2B1

Gene name

retinoid X receptor, alpha

Gene Type

protein-coding

Chromosome

9

Genomics Location

9q34.3

Known cancer genes

Yes

Protein products

Retinoid X nuclear receptor alpha

RXRA protein

FLJ00280 protein

FLJ00318 protein

Retinoic acid receptor RXR-alpha

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:10477
MIM:180245
Ensembl:ENSG00000186350
HPRD:01577
RefSeq Genomic nucleotide accession:AC_000052
RefSeq Genomic nucleotide gi:89161215

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0000790

nuclear chromatin

GO:0001889

liver development

GO:0001890

placenta development

GO:0003677

DNA binding

GO:0003690

double-stranded DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003706

ligand-regulated transcription factor activity

GO:0003707

steroid hormone receptor activity

GO:0003708

retinoic acid receptor activity

GO:0003713

transcription coactivator activity

GO:0004886

retinoid-X receptor activity

GO:0005496

steroid binding

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0006351

transcription, DNA-dependent

GO:0006766

vitamin metabolic process

GO:0006954

inflammatory response

GO:0007494

midgut development

GO:0007507

heart development

GO:0007565

female pregnancy

GO:0007568

aging

GO:0007584

response to nutrient

GO:0008203

cholesterol metabolic process

GO:0008270

zinc ion binding

GO:0008285

negative regulation of cell proliferation

GO:0010269

response to selenium ion

GO:0010467

gene expression

GO:0014070

response to organic cyclic compound

GO:0019899

enzyme binding

GO:0030424

axon

GO:0031103

axon regeneration

GO:0032526

response to retinoic acid

GO:0032869

cellular response to insulin stimulus

GO:0033280

response to vitamin D

GO:0034339

regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

GO:0042809

vitamin D receptor binding

GO:0043065

positive regulation of apoptosis

GO:0043565

sequence-specific DNA binding

GO:0044255

cellular lipid metabolic process

GO:0044323

retinoic acid-responsive element binding

GO:0044419

interspecies interaction between organisms

GO:0045471

response to ethanol

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046872

metal ion binding

GO:0046982

protein heterodimerization activity

GO:0048384

retinoic acid receptor signaling pathway

GO:0051384

response to glucocorticoid stimulus

GO:0055010

ventricular cardiac muscle tissue morphogenesis

GO:0055012

ventricular cardiac muscle cell differentiation

GO:0060038

cardiac muscle cell proliferation

GO:0060528

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

GO:0060687

regulation of branching involved in prostate gland morphogenesis

GO:0070644

vitamin D response element binding