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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG004298

Entrez Gene ID

6352

Official Gene Symbol

CCL5

Synonyms

D17S136E|MGC17164|RANTES|SCYA5|SISd|TCP228

Gene name

chemokine (C-C motif) ligand 5

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q11.2-q12

Protein products

C-C motif chemokine 5

Chemokine (C-C motif) ligand 5

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Alcoholic hepatitis

Alcoholic liver cirrhosis

Hepatocellular carcinoma

Cross infection of hepatitis virus and HIV

Database cross reference

HGNC:10632
MIM:187011
Ensembl:ENSG00000161570
HPRD:01751
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0002407

dendritic cell chemotaxis

GO:0002676

regulation of chronic inflammatory response

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005625

soluble fraction

GO:0005737

cytoplasm

GO:0006935

chemotaxis

GO:0006955

immune response

GO:0007159

leukocyte cell-cell adhesion

GO:0007267

cell-cell signaling

GO:0007568

aging

GO:0008009

chemokine activity

GO:0009615

response to virus

GO:0010535

positive regulation of activation of JAK2 kinase activity

GO:0010759

positive regulation of macrophage chemotaxis

GO:0010820

positive regulation of T cell chemotaxis

GO:0014068

positive regulation of phosphatidylinositol 3-kinase cascade

GO:0014911

positive regulation of smooth muscle cell migration

GO:0030298

receptor signaling protein tyrosine kinase activator activity

GO:0031328

positive regulation of cellular biosynthetic process

GO:0031584

activation of phospholipase D activity

GO:0031622

positive regulation of fever generation

GO:0031726

CCR1 chemokine receptor binding

GO:0031729

CCR4 chemokine receptor binding

GO:0031730

CCR5 chemokine receptor binding

GO:0032496

response to lipopolysaccharide

GO:0032868

response to insulin stimulus

GO:0033634

positive regulation of cell-cell adhesion mediated by integrin

GO:0034112

positive regulation of homotypic cell-cell adhesion

GO:0034612

response to tumor necrosis factor

GO:0042056

chemoattractant activity

GO:0042102

positive regulation of T cell proliferation

GO:0042119

neutrophil activation

GO:0042327

positive regulation of phosphorylation

GO:0042379

chemokine receptor binding

GO:0042493

response to drug

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

GO:0042803

protein homodimerization activity

GO:0043621

protein self-association

GO:0043623

cellular protein complex assembly

GO:0045070

positive regulation of viral genome replication

GO:0045071

negative regulation of viral genome replication

GO:0045089

positive regulation of innate immune response

GO:0045672

positive regulation of osteoclast differentiation

GO:0045785

positive regulation of cell adhesion

GO:0045948

positive regulation of translational initiation

GO:0046427

positive regulation of JAK-STAT cascade

GO:0046817

chemokine receptor antagonist activity

GO:0048245

eosinophil chemotaxis

GO:0048246

macrophage chemotaxis

GO:0048247

lymphocyte chemotaxis

GO:0048661

positive regulation of smooth muscle cell proliferation

GO:0050863

regulation of T cell activation

GO:0050918

positive chemotaxis

GO:0051262

protein tetramerization

GO:0051384

response to glucocorticoid stimulus

GO:0070098

chemokine-mediated signaling pathway

GO:0070100

negative regulation of chemokine-mediated signaling pathway

GO:0070233

negative regulation of T cell apoptosis

GO:0070234

positive regulation of T cell apoptosis

GO:0090026

positive regulation of monocyte chemotaxis