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Gene basic information

LiverAtlas Gene ID

HuLG004428

Entrez Gene ID

6521

Official Gene Symbol

SLC4A1

Synonyms

AE1|BND3|CD233|DI|EMPB3|EPB3|FR|MGC116750|MGC116753|MGC126619|MGC126623|RTA1A|SW|WD|WD1|WR

Gene name

solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q21-q22

Known cancer genes

Yes

Protein products

Band 3 anion transport protein

Anion exchange protein 1

Anion exchange protein 1

Solute carrier family 4, anion exchanger, member 1

Erythroid anion exchange protein

Erythroid anion exchange protein

Related liver disease name

Primary biliary cirrhosis

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:11027
MIM:109270
Ensembl:ENSG00000004939
HPRD:00175
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

 

Ontology annotation

GO ID

GO annotation

GO:0003779

actin binding

GO:0005215

transporter activity

GO:0005452

inorganic anion exchanger activity

GO:0005515

protein binding

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006811

ion transport

GO:0006820

anion transport

GO:0006821

chloride transport

GO:0006873

cellular ion homeostasis

GO:0008022

protein C-terminus binding

GO:0008509

anion transmembrane transporter activity

GO:0015108

chloride transmembrane transporter activity

GO:0015301

anion:anion antiporter activity

GO:0015701

bicarbonate transport

GO:0016021

integral to membrane

GO:0016323

basolateral plasma membrane

GO:0030018

Z disc

GO:0030506

ankyrin binding

GO:0030863

cortical cytoskeleton

GO:0042803

protein homodimerization activity

GO:0043495

protein anchor

GO:0055085

transmembrane transport