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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG004439

Entrez Gene ID

6532

Official Gene Symbol

SLC6A4

Synonyms

5NHTT|5NHTTLPR|5HTT|HTT|OCD1|SERT|hSERT

Gene name

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q11.2

Known cancer genes

Yes

Protein products

Transporter

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Solute carrier family 6 member 4

Transporter

Transporter

Sodium-dependent serotonin transporter

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Alcoholic liver cirrhosis

Database cross reference

HGNC:11050
MIM:182138
Ensembl:ENSG00000108576
HPRD:01640
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

 

Ontology annotation

GO ID

GO annotation

GO:0005335

serotonin:sodium symporter activity

GO:0005515

protein binding

GO:0005624

membrane fraction

GO:0005768

endosome

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006836

neurotransmitter transport

GO:0006837

serotonin transport

GO:0008504

monoamine transmembrane transporter activity

GO:0009636

response to toxin

GO:0010008

endosome membrane

GO:0010628

positive regulation of gene expression

GO:0012505

endomembrane system

GO:0015222

serotonin transmembrane transporter activity

GO:0015293

symporter activity

GO:0015844

monoamine transport

GO:0017022

myosin binding

GO:0017075

syntaxin-1 binding

GO:0017137

Rab GTPase binding

GO:0019811

cocaine binding

GO:0021794

thalamus development

GO:0042803

protein homodimerization activity

GO:0045121

membrane raft

GO:0045787

positive regulation of cell cycle

GO:0050998

nitric-oxide synthase binding

GO:0051015

actin filament binding

GO:0051259

protein oligomerization

GO:0051260

protein homooligomerization

GO:0051610

serotonin uptake