Gene basic information
| LiverAtlas Gene ID |
HuLG004504 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMO |
|
Synonyms |
FZD11|Gx|SMOH |
|
Gene name |
smoothened, frizzled family receptor |
|
Gene Type |
protein-coding |
|
Chromosome |
7 |
|
Genomics Location |
7q32.3 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:11119
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001570 |
vasculogenesis |
|
GO:0001649 |
osteoblast differentiation |
|
GO:0001701 |
in utero embryonic development |
|
GO:0001708 |
cell fate specification |
|
GO:0001755 |
neural crest cell migration |
|
GO:0002052 |
positive regulation of neuroblast proliferation |
|
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
|
GO:0003007 |
heart morphogenesis |
|
GO:0004871 |
signal transducer activity |
|
GO:0004872 |
receptor activity |
|
GO:0004930 |
G-protein coupled receptor activity |
|
GO:0005488 |
binding |
|
GO:0005515 |
protein binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005886 |
plasma membrane |
|
GO:0005929 |
cilium |
|
GO:0007165 |
signal transduction |
|
GO:0007275 |
multicellular organismal development |
|
GO:0007283 |
spermatogenesis |
|
GO:0007368 |
determination of left/right symmetry |
|
GO:0007389 |
pattern specification process |
|
GO:0008406 |
gonad development |
|
GO:0009611 |
response to wounding |
|
GO:0010002 |
cardioblast differentiation |
|
GO:0010033 |
response to organic substance |
|
GO:0010468 |
regulation of gene expression |
|
GO:0016021 |
integral to membrane |
|
GO:0017147 |
Wnt-protein binding |
|
GO:0021508 |
floor plate formation |
|
GO:0021561 |
facial nerve development |
|
GO:0021696 |
cerebellar cortex morphogenesis |
|
GO:0021904 |
dorsal/ventral neural tube patterning |
|
GO:0021910 |
smoothened signaling pathway involved in ventral spinal cord patterning |
|
GO:0021938 |
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation |
|
GO:0021953 |
central nervous system neuron differentiation |
|
GO:0021984 |
adenohypophysis development |
|
GO:0030165 |
PDZ domain binding |
|
GO:0031017 |
exocrine pancreas development |
|
GO:0031076 |
embryonic camera-type eye development |
|
GO:0031102 |
neuron projection regeneration |
|
GO:0032474 |
otolith morphogenesis |
|
GO:0033687 |
osteoblast proliferation |
|
GO:0035264 |
multicellular organism growth |
|
GO:0042307 |
positive regulation of protein import into nucleus |
|
GO:0042475 |
odontogenesis of dentine-containing tooth |
|
GO:0042693 |
muscle cell fate commitment |
|
GO:0042813 |
Wnt receptor activity |
|
GO:0043025 |
neuronal cell body |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043392 |
negative regulation of DNA binding |
|
GO:0045880 |
positive regulation of smoothened signaling pathway |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0048468 |
cell development |
|
GO:0048557 |
embryonic digestive tract morphogenesis |
|
GO:0048589 |
developmental growth |
|
GO:0048663 |
neuron fate commitment |
|
GO:0048702 |
embryonic neurocranium morphogenesis |
|
GO:0048703 |
embryonic viscerocranium morphogenesis |
|
GO:0048752 |
semicircular canal morphogenesis |
|
GO:0048846 |
axon extension involved in axon guidance |
|
GO:0050679 |
positive regulation of epithelial cell proliferation |
|
GO:0050821 |
protein stabilization |
|
GO:0060070 |
canonical Wnt receptor signaling pathway |
|
GO:0060684 |
epithelial-mesenchymal cell signaling |
|
GO:0060830 |
ciliary receptor clustering involved in smoothened signaling pathway |
