HuLG004598

Entrez Gene ID

6714

Official Gene Symbol

SRC

Synonyms

ASV|SRC1|cNSRC|p60NSrc

Gene name

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Gene Type

protein-coding

Chromosome

20

Genomics Location

20q12-q13

Known cancer genes

Yes

Protein products

Tyrosine kinase pp60c-src

Proto-oncogene tyrosine-protein kinase Src

Related liver disease name

Hepatitis B

Hepatocellular carcinoma

Database cross reference

HGNC:11283
MIM:190090
Ensembl:ENSG00000197122
HPRD:01819
RefSeq Genomic nucleotide accession:AC_000063
RefSeq Genomic nucleotide gi:89161200

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

GO annotation

GO:0000166

nucleotide binding

GO:0001101

response to acid

GO:0004672

protein kinase activity

GO:0004713

protein tyrosine kinase activity

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO:0005070

SH3/SH2 adaptor activity

GO:0005080

protein kinase C binding

GO:0005102

receptor binding

GO:0005158

insulin receptor binding

GO:0005178

integrin binding

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005739

mitochondrion

GO:0005743

mitochondrial inner membrane

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0005901

caveola

GO:0006950

response to stress

GO:0007165

signal transduction

GO:0007172

signal complex assembly

GO:0007173

epidermal growth factor receptor signaling pathway

GO:0007243

intracellular protein kinase cascade

GO:0007265

Ras protein signal transduction

GO:0007411

axon guidance

GO:0007596

blood coagulation

GO:0008022

protein C-terminus binding

GO:0008283

cell proliferation

GO:0008543

fibroblast growth factor receptor signaling pathway

GO:0009612

response to mechanical stimulus

GO:0009615

response to virus

GO:0010628

positive regulation of gene expression

GO:0010740

positive regulation of intracellular protein kinase cascade

GO:0010907

positive regulation of glucose metabolic process

GO:0014069

postsynaptic density

GO:0014911

positive regulation of smooth muscle cell migration

GO:0016044

cellular membrane organization

GO:0016301

kinase activity

GO:0016310

phosphorylation

GO:0016337

cell-cell adhesion

GO:0018108

peptidyl-tyrosine phosphorylation

GO:0019717

synaptosome

GO:0020037

heme binding

GO:0030168

platelet activation

GO:0030900

forebrain development

GO:0031295

T cell costimulation

GO:0031667

response to nutrient levels

GO:0032869

cellular response to insulin stimulus

GO:0033146

regulation of estrogen receptor signaling pathway

GO:0033625

positive regulation of integrin activation

GO:0034329

cell junction assembly

GO:0042169

SH2 domain binding

GO:0042493

response to drug

GO:0042542

response to hydrogen peroxide

GO:0043065

positive regulation of apoptosis

GO:0043114

regulation of vascular permeability

GO:0044325

ion channel binding

GO:0044419

interspecies interaction between organisms

GO:0045056

transcytosis

GO:0045124

regulation of bone resorption

GO:0045453

bone resorption

GO:0045785

positive regulation of cell adhesion

GO:0046628

positive regulation of insulin receptor signaling pathway

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO:0048011

nerve growth factor receptor signaling pathway

GO:0048477

oogenesis

GO:0050715

positive regulation of cytokine secretion

GO:0050839

cell adhesion molecule binding

GO:0050900

leukocyte migration

GO:0051222

positive regulation of protein transport

GO:0051385

response to mineralocorticoid stimulus

GO:0051602

response to electrical stimulus

GO:0060065

uterus development

GO:0060444

branching involved in mammary gland duct morphogenesis

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO:0070555

response to interleukin-1

GO:0071222

cellular response to lipopolysaccharide

GO:0071398

cellular response to fatty acid

GO:0071445

cellular response to protein stimulus

GO:0071456

cellular response to hypoxia

GO:0090263

positive regulation of canonical Wnt receptor signaling pathway