Gene basic information
| LiverAtlas Gene ID |
HuLG004642 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
STAT1 |
|
Synonyms |
DKFZp686B04100|ISGFN3|STAT91 |
|
Gene name |
signal transducer and activator of transcription 1, 91kDa |
|
Gene Type |
protein-coding |
|
Chromosome |
2 |
|
Genomics Location |
2q32.2 |
|
Known cancer genes |
Yes |
|
Protein products |
Signal transducer and activator of transcription 1-alpha/beta |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:11362
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
|
GO:0000983 |
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity |
|
GO:0003677 |
DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0004871 |
signal transducer activity |
|
GO:0005509 |
calcium ion binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006366 |
transcription from RNA polymerase II promoter |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0007165 |
signal transduction |
|
GO:0007249 |
I-kappaB kinase/NF-kappaB cascade |
|
GO:0007259 |
JAK-STAT cascade |
|
GO:0007260 |
tyrosine phosphorylation of STAT protein |
|
GO:0007584 |
response to nutrient |
|
GO:0008015 |
blood circulation |
|
GO:0009612 |
response to mechanical stimulus |
|
GO:0009615 |
response to virus |
|
GO:0009617 |
response to bacterium |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0019221 |
cytokine-mediated signaling pathway |
|
GO:0030424 |
axon |
|
GO:0030425 |
dendrite |
|
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0032869 |
cellular response to insulin stimulus |
|
GO:0034097 |
response to cytokine stimulus |
|
GO:0042493 |
response to drug |
|
GO:0042542 |
response to hydrogen peroxide |
|
GO:0043330 |
response to exogenous dsRNA |
|
GO:0043434 |
response to peptide hormone stimulus |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
|
GO:0051591 |
response to cAMP |
|
GO:0060333 |
interferon-gamma-mediated signaling pathway |
|
GO:0060334 |
regulation of interferon-gamma-mediated signaling pathway |
|
GO:0060337 |
type I interferon-mediated signaling pathway |
|
GO:0060338 |
regulation of type I interferon-mediated signaling pathway |
