Gene basic information
| LiverAtlas Gene ID |
HuLG004697 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SYK |
|
Synonyms |
DKFZp313N1010|FLJ25043|FLJ37489 |
|
Gene name |
spleen tyrosine kinase |
|
Gene Type |
protein-coding |
|
Chromosome |
9 |
|
Genomics Location |
9q22 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ76165, highly similar to Homo sapiens spleen tyrosine kinase (SYK), mRNA |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:11491
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0001820 |
serotonin secretion |
|
GO:0004672 |
protein kinase activity |
|
GO:0004713 |
protein tyrosine kinase activity |
|
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
|
GO:0004716 |
receptor signaling protein tyrosine kinase activity |
|
GO:0005178 |
integrin binding |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006461 |
protein complex assembly |
|
GO:0006468 |
protein phosphorylation |
|
GO:0007159 |
leukocyte cell-cell adhesion |
|
GO:0007167 |
enzyme linked receptor protein signaling pathway |
|
GO:0007229 |
integrin-mediated signaling pathway |
|
GO:0007257 |
activation of JUN kinase activity |
|
GO:0007596 |
blood coagulation |
|
GO:0008283 |
cell proliferation |
|
GO:0009887 |
organ morphogenesis |
|
GO:0019370 |
leukotriene biosynthetic process |
|
GO:0019815 |
B cell receptor complex |
|
GO:0019904 |
protein domain specific binding |
|
GO:0030168 |
platelet activation |
|
GO:0030593 |
neutrophil chemotaxis |
|
GO:0035556 |
intracellular signal transduction |
|
GO:0042101 |
T cell receptor complex |
|
GO:0043306 |
positive regulation of mast cell degranulation |
|
GO:0043366 |
beta selection |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045401 |
positive regulation of interleukin-3 biosynthetic process |
|
GO:0045425 |
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process |
|
GO:0045579 |
positive regulation of B cell differentiation |
|
GO:0045588 |
positive regulation of gamma-delta T cell differentiation |
|
GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
|
GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
|
GO:0046777 |
protein autophosphorylation |
|
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
|
GO:0050776 |
regulation of immune response |
|
GO:0050850 |
positive regulation of calcium-mediated signaling |
|
GO:0050853 |
B cell receptor signaling pathway |
