Gene basic information
| LiverAtlas Gene ID |
HuLG004766 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TCF7L2 |
|
Synonyms |
TCFN4|TCF4 |
|
Gene name |
transcription factor 7-like 2 (T-cell specific, HMG-box) |
|
Gene Type |
protein-coding |
|
Chromosome |
10 |
|
Genomics Location |
10q25.3 |
|
Known cancer genes |
Yes |
|
Protein products |
TCF7L2 isoform pFC8A TCF7L2 A3,ex1-12,13,13a TCF7L2 isoform pFC8A TCF7L2 H7 ex1-11-13-13b TCF7L2 isoform pFC8A TCF7L2 B1 ex1-11-12-13-13b TCF7L2 isoform pFC8A TCF7L2 ex1-11-12-14 TCF7L2 isoform pFC8A TCF7L2 B4 ex1-no4-11-14 TCF7L2 isoform pFC8A TCF7L2 ex1-11-13-14 Transcription factor 7-like 2 (T-cell specific, HMG-box) Transcription factor 7-like 2 (T-cell specific, HMG-box) Transcription factor 7-like 2 (T-cell specific, HMG-box) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:11641
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001568 |
blood vessel development |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005667 |
transcription factor complex |
|
GO:0005829 |
cytosol |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
|
GO:0006916 |
anti-apoptosis |
|
GO:0007050 |
cell cycle arrest |
|
GO:0008013 |
beta-catenin binding |
|
GO:0008134 |
transcription factor binding |
|
GO:0008283 |
cell proliferation |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0010909 |
positive regulation of heparan sulfate proteoglycan biosynthetic process |
|
GO:0014003 |
oligodendrocyte development |
|
GO:0016605 |
PML body |
|
GO:0019901 |
protein kinase binding |
|
GO:0021915 |
neural tube development |
|
GO:0030538 |
embryonic genitalia morphogenesis |
|
GO:0031016 |
pancreas development |
|
GO:0032024 |
positive regulation of insulin secretion |
|
GO:0032092 |
positive regulation of protein binding |
|
GO:0032350 |
regulation of hormone metabolic process |
|
GO:0032993 |
protein-DNA complex |
|
GO:0035019 |
somatic stem cell maintenance |
|
GO:0035257 |
nuclear hormone receptor binding |
|
GO:0042593 |
glucose homeostasis |
|
GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0043570 |
maintenance of DNA repeat elements |
|
GO:0044334 |
canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition |
|
GO:0045295 |
gamma-catenin binding |
|
GO:0045444 |
fat cell differentiation |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046827 |
positive regulation of protein export from nucleus |
|
GO:0048557 |
embryonic digestive tract morphogenesis |
|
GO:0048619 |
embryonic hindgut morphogenesis |
|
GO:0048625 |
myoblast cell fate commitment |
|
GO:0048660 |
regulation of smooth muscle cell proliferation |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0060070 |
canonical Wnt receptor signaling pathway |
|
GO:0070016 |
armadillo repeat domain binding |
|
GO:0070369 |
beta-catenin-TCF7L2 complex |
|
GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
