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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG004830

Entrez Gene ID

7037

Official Gene Symbol

TFRC

Synonyms

CD71|TFR|TFR1|TRFR

Gene name

transferrin receptor (p90, CD71)

Gene Type

protein-coding

Chromosome

3

Genomics Location

3q29

Known cancer genes

Yes

Protein products

cDNA FLJ75881, highly similar to Homo sapiens transferrin receptor (p90, CD71) (TFRC), mRNA

Transferrin receptor protein 1

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Alcoholic liver disease

Hepatocellular carcinoma

Database cross reference

HGNC:11763
MIM:190010
Ensembl:ENSG00000072274
HPRD:01812
RefSeq Genomic nucleotide accession:AC_000046
RefSeq Genomic nucleotide gi:89161204

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001666

response to hypoxia

GO:0004872

receptor activity

GO:0004998

transferrin receptor activity

GO:0005576

extracellular region

GO:0005739

mitochondrion

GO:0005768

endosome

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0005905

coated pit

GO:0006508

proteolysis

GO:0006879

cellular iron ion homeostasis

GO:0006897

endocytosis

GO:0006953

acute-phase response

GO:0007568

aging

GO:0007584

response to nutrient

GO:0008233

peptidase activity

GO:0010033

response to organic substance

GO:0010035

response to inorganic substance

GO:0010039

response to iron ion

GO:0010042

response to manganese ion

GO:0016020

membrane

GO:0016023

cytoplasmic membrane-bounded vesicle

GO:0030544

Hsp70 protein binding

GO:0032526

response to retinoic acid

GO:0033572

transferrin transport

GO:0042470

melanosome

GO:0044419

interspecies interaction between organisms

GO:0046688

response to copper ion

GO:0048471

perinuclear region of cytoplasm

GO:0051087

chaperone binding

GO:0055085

transmembrane transport

GO:0070062

extracellular vesicular exosome