Gene basic information
| LiverAtlas Gene ID |
HuLG004833 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TGFB1 |
|
Synonyms |
CED|DPD1|LAP|TGFB|TGFbeta |
|
Gene name |
transforming growth factor, beta 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
19 |
|
Genomics Location |
19q13.2|19q13.1 |
|
Known cancer genes |
Yes |
|
Protein products |
Transforming growth factor beta 1 Transforming growth factor beta 1 Transforming growth factor beta 1 Transforming growth factor beta 1 Transforming growth factor beta 1 |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis B infection Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:11766
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000060 |
protein import into nucleus, translocation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001657 |
ureteric bud development |
|
GO:0001666 |
response to hypoxia |
|
GO:0001763 |
morphogenesis of a branching structure |
|
GO:0001933 |
negative regulation of protein phosphorylation |
|
GO:0001934 |
positive regulation of protein phosphorylation |
|
GO:0002028 |
regulation of sodium ion transport |
|
GO:0002062 |
chondrocyte differentiation |
|
GO:0002244 |
hemopoietic progenitor cell differentiation |
|
GO:0002248 |
connective tissue replacement involved in inflammatory response wound healing |
|
GO:0002460 |
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
|
GO:0002513 |
tolerance induction to self antigen |
|
GO:0002576 |
platelet degranulation |
|
GO:0005114 |
type II transforming growth factor beta receptor binding |
|
GO:0005160 |
transforming growth factor beta receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005578 |
proteinaceous extracellular matrix |
|
GO:0005615 |
extracellular space |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005796 |
Golgi lumen |
|
GO:0006468 |
protein phosphorylation |
|
GO:0006611 |
protein export from nucleus |
|
GO:0006754 |
ATP biosynthetic process |
|
GO:0006796 |
phosphate metabolic process |
|
GO:0006874 |
cellular calcium ion homeostasis |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006954 |
inflammatory response |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007173 |
epidermal growth factor receptor signaling pathway |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0007183 |
SMAD protein complex assembly |
|
GO:0007184 |
SMAD protein import into nucleus |
|
GO:0007406 |
negative regulation of neuroblast proliferation |
|
GO:0007435 |
salivary gland morphogenesis |
|
GO:0007492 |
endoderm development |
|
GO:0007565 |
female pregnancy |
|
GO:0007568 |
aging |
|
GO:0007596 |
blood coagulation |
|
GO:0008083 |
growth factor activity |
|
GO:0008156 |
negative regulation of DNA replication |
|
GO:0008219 |
cell death |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008354 |
germ cell migration |
|
GO:0009314 |
response to radiation |
|
GO:0009611 |
response to wounding |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0009790 |
embryo development |
|
GO:0009817 |
defense response to fungus, incompatible interaction |
|
GO:0009986 |
cell surface |
|
GO:0010628 |
positive regulation of gene expression |
|
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
|
GO:0010742 |
macrophage derived foam cell differentiation |
|
GO:0010763 |
positive regulation of fibroblast migration |
|
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
|
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
|
GO:0010936 |
negative regulation of macrophage cytokine production |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0016202 |
regulation of striated muscle tissue development |
|
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0019048 |
virus-host interaction |
|
GO:0019049 |
evasion of host defenses by virus |
|
GO:0019058 |
viral infectious cycle |
|
GO:0022408 |
negative regulation of cell-cell adhesion |
|
GO:0030141 |
stored secretory granule |
|
GO:0030168 |
platelet activation |
|
GO:0030279 |
negative regulation of ossification |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030334 |
regulation of cell migration |
|
GO:0030424 |
axon |
|
GO:0030501 |
positive regulation of bone mineralization |
|
GO:0030879 |
mammary gland development |
|
GO:0031065 |
positive regulation of histone deacetylation |
|
GO:0031093 |
platelet alpha granule lumen |
|
GO:0031100 |
organ regeneration |
|
GO:0031536 |
positive regulation of exit from mitosis |
|
GO:0031575 |
mitotic cell cycle G1/S transition checkpoint |
|
GO:0032270 |
positive regulation of cellular protein metabolic process |
|
GO:0032355 |
response to estradiol stimulus |
|
GO:0032570 |
response to progesterone stimulus |
|
GO:0032740 |
positive regulation of interleukin-17 production |
|
GO:0032801 |
receptor catabolic process |
|
GO:0032943 |
mononuclear cell proliferation |
|
GO:0032967 |
positive regulation of collagen biosynthetic process |
|
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
|
GO:0033280 |
response to vitamin D |
|
GO:0034616 |
response to laminar fluid shear stress |
|
GO:0035066 |
positive regulation of histone acetylation |
|
GO:0035307 |
positive regulation of protein dephosphorylation |
|
GO:0042130 |
negative regulation of T cell proliferation |
|
GO:0042306 |
regulation of protein import into nucleus |
|
GO:0042482 |
positive regulation of odontogenesis |
|
GO:0042493 |
response to drug |
|
GO:0042552 |
myelination |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043011 |
myeloid dendritic cell differentiation |
|
GO:0043025 |
neuronal cell body |
|
GO:0043029 |
T cell homeostasis |
|
GO:0043406 |
positive regulation of MAP kinase activity |
|
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
|
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
|
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
|
GO:0043932 |
ossification involved in bone remodeling |
|
GO:0045066 |
regulatory T cell differentiation |
|
GO:0045216 |
cell-cell junction organization |
|
GO:0045599 |
negative regulation of fat cell differentiation |
|
GO:0045786 |
negative regulation of cell cycle |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045930 |
negative regulation of mitotic cell cycle |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046732 |
active induction of host immune response by virus |
|
GO:0046982 |
protein heterodimerization activity |
|
GO:0047485 |
protein N-terminus binding |
|
GO:0048298 |
positive regulation of isotype switching to IgA isotypes |
|
GO:0048535 |
lymph node development |
|
GO:0048565 |
digestive tract development |
|
GO:0048839 |
inner ear development |
|
GO:0050679 |
positive regulation of epithelial cell proliferation |
|
GO:0050680 |
negative regulation of epithelial cell proliferation |
|
GO:0050714 |
positive regulation of protein secretion |
|
GO:0050765 |
negative regulation of phagocytosis |
|
GO:0050777 |
negative regulation of immune response |
|
GO:0050921 |
positive regulation of chemotaxis |
|
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
|
GO:0051098 |
regulation of binding |
|
GO:0051101 |
regulation of DNA binding |
|
GO:0051152 |
positive regulation of smooth muscle cell differentiation |
|
GO:0051280 |
negative regulation of release of sequestered calcium ion into cytosol |
|
GO:0051781 |
positive regulation of cell division |
|
GO:0051789 |
response to protein stimulus |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0060364 |
frontal suture morphogenesis |
|
GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
|
GO:0060391 |
positive regulation of SMAD protein import into nucleus |
|
GO:0060744 |
mammary gland branching involved in thelarche |
|
GO:0060751 |
branch elongation involved in mammary gland duct branching |
|
GO:0060762 |
regulation of branching involved in mammary gland duct morphogenesis |
|
GO:0070306 |
lens fiber cell differentiation |
|
GO:0070723 |
response to cholesterol |
|
GO:0071158 |
positive regulation of cell cycle arrest |
|
GO:0071363 |
cellular response to growth factor stimulus |
|
GO:0071549 |
cellular response to dexamethasone stimulus |
|
GO:0090190 |
positive regulation of branching involved in ureteric bud morphogenesis |
