HuLG004839

Entrez Gene ID

7046

Official Gene Symbol

TGFBR1

Synonyms

AAT5|ACVRLK4|ALKN5|ALK5|LDS1A|LDS2A|SKR4|TGFRN1

Gene name

transforming growth factor, beta receptor 1

Gene Type

protein-coding

Chromosome

9

Genomics Location

9q22

Known cancer genes

Yes

Protein products

Transforming growth factor beta receptor I

TGF-beta receptor type-1

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Liver fibrosis and liver cirrhosis caused by hepatitis C infection

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:11772
MIM:190181
Ensembl:ENSG00000106799
HPRD:01822
RefSeq Genomic nucleotide accession:AC_000052
RefSeq Genomic nucleotide gi:89161215

GO annotation

GO:0000166

nucleotide binding

GO:0000186

activation of MAPKK activity

GO:0001501

skeletal system development

GO:0001666

response to hypoxia

GO:0001701

in utero embryonic development

GO:0001822

kidney development

GO:0001824

blastocyst development

GO:0004674

protein serine/threonine kinase activity

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

GO:0004872

receptor activity

GO:0005024

transforming growth factor beta receptor activity

GO:0005025

transforming growth factor beta receptor activity, type I

GO:0005114

type II transforming growth factor beta receptor binding

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005886

plasma membrane

GO:0006355

regulation of transcription, DNA-dependent

GO:0006468

protein phosphorylation

GO:0006917

induction of apoptosis

GO:0007165

signal transduction

GO:0007179

transforming growth factor beta receptor signaling pathway

GO:0007507

heart development

GO:0007566

embryo implantation

GO:0007568

aging

GO:0008284

positive regulation of cell proliferation

GO:0008354

germ cell migration

GO:0009636

response to toxin

GO:0009790

embryo development

GO:0009791

post-embryonic development

GO:0009952

anterior/posterior pattern formation

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

GO:0014070

response to organic cyclic compound

GO:0016021

integral to membrane

GO:0016323

basolateral plasma membrane

GO:0016324

apical plasma membrane

GO:0018105

peptidyl-serine phosphorylation

GO:0018107

peptidyl-threonine phosphorylation

GO:0019838

growth factor binding

GO:0030199

collagen fibril organization

GO:0030307

positive regulation of cell growth

GO:0030324

lung development

GO:0031100

organ regeneration

GO:0031625

ubiquitin protein ligase binding

GO:0032403

protein complex binding

GO:0034695

response to prostaglandin E stimulus

GO:0043066

negative regulation of apoptosis

GO:0043235

receptor complex

GO:0043393

regulation of protein binding

GO:0043627

response to estrogen stimulus

GO:0044459

plasma membrane part

GO:0045602

negative regulation of endothelial cell differentiation

GO:0045885

positive regulation of survival gene product expression

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0046332

SMAD binding

GO:0046777

protein autophosphorylation

GO:0046872

metal ion binding

GO:0046982

protein heterodimerization activity

GO:0048538

thymus development

GO:0048565

digestive tract development

GO:0048663

neuron fate commitment

GO:0048701

embryonic cranial skeleton morphogenesis

GO:0048705

skeletal system morphogenesis

GO:0048844

artery morphogenesis

GO:0048870

cell motility

GO:0050431

transforming growth factor beta binding

GO:0051272

positive regulation of cellular component movement

GO:0051491

positive regulation of filopodium assembly

GO:0051602

response to electrical stimulus

GO:0051897

positive regulation of protein kinase B signaling cascade

GO:0060017

parathyroid gland development

GO:0060021

palate development

GO:0060037

pharyngeal system development

GO:0060389

pathway-restricted SMAD protein phosphorylation

GO:0060391

positive regulation of SMAD protein import into nucleus

GO:0070022

transforming growth factor beta receptor complex

GO:0070411

I-SMAD binding

GO:0070723

response to cholesterol