Gene basic information
| LiverAtlas Gene ID |
HuLG004849 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
THBS1 |
|
Synonyms |
THBS|THBSN1|TSP|TSPN1|TSP1 |
|
Gene name |
thrombospondin 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
15 |
|
Genomics Location |
15q15 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:11785
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0001666 |
response to hypoxia |
|
GO:0001786 |
phosphatidylserine binding |
|
GO:0001937 |
negative regulation of endothelial cell proliferation |
|
GO:0001948 |
glycoprotein binding |
|
GO:0001953 |
negative regulation of cell-matrix adhesion |
|
GO:0001968 |
fibronectin binding |
|
GO:0002040 |
sprouting angiogenesis |
|
GO:0002544 |
chronic inflammatory response |
|
GO:0002576 |
platelet degranulation |
|
GO:0002581 |
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
|
GO:0002605 |
negative regulation of dendritic cell antigen processing and presentation |
|
GO:0005178 |
integrin binding |
|
GO:0005198 |
structural molecule activity |
|
GO:0005509 |
calcium ion binding |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005577 |
fibrinogen complex |
|
GO:0005615 |
extracellular space |
|
GO:0006915 |
apoptosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006955 |
immune response |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007155 |
cell adhesion |
|
GO:0007596 |
blood coagulation |
|
GO:0008201 |
heparin binding |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0009897 |
external side of plasma membrane |
|
GO:0010595 |
positive regulation of endothelial cell migration |
|
GO:0010596 |
negative regulation of endothelial cell migration |
|
GO:0010748 |
negative regulation of plasma membrane long-chain fatty acid transport |
|
GO:0010751 |
negative regulation of nitric oxide mediated signal transduction |
|
GO:0010754 |
negative regulation of cGMP-mediated signaling |
|
GO:0010757 |
negative regulation of plasminogen activation |
|
GO:0010759 |
positive regulation of macrophage chemotaxis |
|
GO:0010763 |
positive regulation of fibroblast migration |
|
GO:0016477 |
cell migration |
|
GO:0016525 |
negative regulation of angiogenesis |
|
GO:0018149 |
peptide cross-linking |
|
GO:0030141 |
stored secretory granule |
|
GO:0030168 |
platelet activation |
|
GO:0030169 |
low-density lipoprotein particle binding |
|
GO:0030194 |
positive regulation of blood coagulation |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0031012 |
extracellular matrix |
|
GO:0031091 |
platelet alpha granule |
|
GO:0031093 |
platelet alpha granule lumen |
|
GO:0032026 |
response to magnesium ion |
|
GO:0032570 |
response to progesterone stimulus |
|
GO:0032695 |
negative regulation of interleukin-12 production |
|
GO:0032914 |
positive regulation of transforming growth factor-beta1 production |
|
GO:0034605 |
cellular response to heat |
|
GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
|
GO:0042327 |
positive regulation of phosphorylation |
|
GO:0042493 |
response to drug |
|
GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
|
GO:0042802 |
identical protein binding |
|
GO:0043032 |
positive regulation of macrophage activation |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043154 |
negative regulation of caspase activity |
|
GO:0043236 |
laminin binding |
|
GO:0043394 |
proteoglycan binding |
|
GO:0043499 |
eukaryotic cell surface binding |
|
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
|
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
|
GO:0043652 |
engulfment of apoptotic cell |
|
GO:0045727 |
positive regulation of translation |
|
GO:0045766 |
positive regulation of angiogenesis |
|
GO:0048603 |
fibroblast growth factor 2 binding |
|
GO:0050431 |
transforming growth factor beta binding |
|
GO:0050921 |
positive regulation of chemotaxis |
|
GO:0051592 |
response to calcium ion |
|
GO:0051895 |
negative regulation of focal adhesion assembly |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0051918 |
negative regulation of fibrinolysis |
|
GO:0070051 |
fibrinogen binding |
|
GO:0070052 |
collagen V binding |
|
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
