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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG004866

Entrez Gene ID

7077

Official Gene Symbol

TIMP2

Synonyms

CSCN21K

Gene name

TIMP metallopeptidase inhibitor 2

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q25

Known cancer genes

Yes

Protein products

Metalloproteinase inhibitor 2

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Liver fibrosis and liver cirrhosis caused by hepatitis C infection

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:11821
MIM:188825
Ensembl:ENSG00000035862
HPRD:01784
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0004857

enzyme inhibitor activity

GO:0005178

integrin binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005604

basement membrane

GO:0008047

enzyme activator activity

GO:0008191

metalloendopeptidase inhibitor activity

GO:0008285

negative regulation of cell proliferation

GO:0009986

cell surface

GO:0030814

regulation of cAMP metabolic process

GO:0043408

regulation of MAPKKK cascade

GO:0045664

regulation of neuron differentiation

GO:0046872

metal ion binding