HuLG004869

Entrez Gene ID

7080

Official Gene Symbol

NKX2-1

Synonyms

BCH|BHC|NKN2|NKX2.1|NKX2A|TEBP|TITF1|TTFN1|TTF1

Gene name

NK2 homeobox 1

Gene Type

protein-coding

Chromosome

14

Genomics Location

14q13

Known cancer genes

Yes

Protein products

Homeobox protein Nkx-2.1

Thyroid transcription factor-1

Related liver disease name

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:11825
MIM:600635
Ensembl:ENSG00000136352
HPRD:02798
RefSeq Genomic nucleotide accession:AC_000057
RefSeq Genomic nucleotide gi:89161192

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001764

neuron migration

GO:0002016

regulation of blood volume by renin-angiotensin

GO:0003677

DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

GO:0005515

protein binding

GO:0005625

soluble fraction

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005667

transcription factor complex

GO:0006351

transcription, DNA-dependent

GO:0006644

phospholipid metabolic process

GO:0007389

pattern specification process

GO:0007411

axon guidance

GO:0007420

brain development

GO:0007492

endoderm development

GO:0007626

locomotory behavior

GO:0007631

feeding behavior

GO:0009725

response to hormone stimulus

GO:0009887

organ morphogenesis

GO:0010628

positive regulation of gene expression

GO:0010719

negative regulation of epithelial to mesenchymal transition

GO:0021759

globus pallidus development

GO:0021766

hippocampus development

GO:0021795

cerebral cortex cell migration

GO:0021798

forebrain dorsal/ventral pattern formation

GO:0021877

forebrain neuron fate commitment

GO:0021892

cerebral cortex GABAergic interneuron differentiation

GO:0021983

pituitary gland development

GO:0030324

lung development

GO:0030336

negative regulation of cell migration

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

GO:0030878

thyroid gland development

GO:0030900

forebrain development

GO:0031128

developmental induction

GO:0032496

response to lipopolysaccharide

GO:0033327

Leydig cell differentiation

GO:0042538

hyperosmotic salinity response

GO:0042696

menarche

GO:0043565

sequence-specific DNA binding

GO:0045471

response to ethanol

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046545

development of primary female sexual characteristics

GO:0048646

anatomical structure formation involved in morphogenesis

GO:0048709

oligodendrocyte differentiation

GO:0060430

lung saccule development

GO:0060441

epithelial tube branching involved in lung morphogenesis

GO:0060486

Clara cell differentiation

GO:0060510

Type II pneumocyte differentiation