Gene basic information
| LiverAtlas Gene ID |
HuLG004886 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TLR4 |
|
Synonyms |
ARMD10|CD284|TOLL|hToll |
|
Gene name |
toll-like receptor 4 |
|
Gene Type |
protein-coding |
|
Chromosome |
9 |
|
Genomics Location |
9q33.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis B infection Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:11850
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0001530 |
lipopolysaccharide binding |
|
GO:0001666 |
response to hypoxia |
|
GO:0001875 |
lipopolysaccharide receptor activity |
|
GO:0002224 |
toll-like receptor signaling pathway |
|
GO:0002282 |
microglial cell activation involved in immune response |
|
GO:0002537 |
nitric oxide production involved in inflammatory response |
|
GO:0002755 |
MyD88-dependent toll-like receptor signaling pathway |
|
GO:0002756 |
MyD88-independent toll-like receptor signaling pathway |
|
GO:0002758 |
innate immune response-activating signal transduction |
|
GO:0003009 |
skeletal muscle contraction |
|
GO:0004872 |
receptor activity |
|
GO:0004888 |
transmembrane receptor activity |
|
GO:0005515 |
protein binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005886 |
plasma membrane |
|
GO:0005887 |
integral to plasma membrane |
|
GO:0006955 |
immune response |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007165 |
signal transduction |
|
GO:0007249 |
I-kappaB kinase/NF-kappaB cascade |
|
GO:0007252 |
I-kappaB phosphorylation |
|
GO:0008063 |
Toll signaling pathway |
|
GO:0009636 |
response to toxin |
|
GO:0009897 |
external side of plasma membrane |
|
GO:0010572 |
positive regulation of platelet activation |
|
GO:0014823 |
response to activity |
|
GO:0016046 |
detection of fungus |
|
GO:0016064 |
immunoglobulin mediated immune response |
|
GO:0030890 |
positive regulation of B cell proliferation |
|
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0032497 |
detection of lipopolysaccharide |
|
GO:0032570 |
response to progesterone stimulus |
|
GO:0032689 |
negative regulation of interferon-gamma production |
|
GO:0032700 |
negative regulation of interleukin-17 production |
|
GO:0032707 |
negative regulation of interleukin-23 production |
|
GO:0032715 |
negative regulation of interleukin-6 production |
|
GO:0032720 |
negative regulation of tumor necrosis factor production |
|
GO:0032722 |
positive regulation of chemokine production |
|
GO:0032727 |
positive regulation of interferon-alpha production |
|
GO:0032728 |
positive regulation of interferon-beta production |
|
GO:0032729 |
positive regulation of interferon-gamma production |
|
GO:0032732 |
positive regulation of interleukin-1 production |
|
GO:0032733 |
positive regulation of interleukin-10 production |
|
GO:0032735 |
positive regulation of interleukin-12 production |
|
GO:0032755 |
positive regulation of interleukin-6 production |
|
GO:0032757 |
positive regulation of interleukin-8 production |
|
GO:0032760 |
positive regulation of tumor necrosis factor production |
|
GO:0032868 |
response to insulin stimulus |
|
GO:0032874 |
positive regulation of stress-activated MAPK cascade |
|
GO:0034130 |
toll-like receptor 1 signaling pathway |
|
GO:0034134 |
toll-like receptor 2 signaling pathway |
|
GO:0034142 |
toll-like receptor 4 signaling pathway |
|
GO:0042088 |
T-helper 1 type immune response |
|
GO:0042116 |
macrophage activation |
|
GO:0042346 |
positive regulation of NF-kappaB import into nucleus |
|
GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
|
GO:0042742 |
defense response to bacterium |
|
GO:0043065 |
positive regulation of apoptosis |
|
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0043388 |
positive regulation of DNA binding |
|
GO:0043548 |
phosphatidylinositol 3-kinase binding |
|
GO:0045084 |
positive regulation of interleukin-12 biosynthetic process |
|
GO:0045087 |
innate immune response |
|
GO:0045121 |
membrane raft |
|
GO:0045348 |
positive regulation of MHC class II biosynthetic process |
|
GO:0045359 |
positive regulation of interferon-beta biosynthetic process |
|
GO:0045416 |
positive regulation of interleukin-8 biosynthetic process |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045471 |
response to ethanol |
|
GO:0045671 |
negative regulation of osteoclast differentiation |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046330 |
positive regulation of JNK cascade |
|
GO:0046696 |
lipopolysaccharide receptor complex |
|
GO:0048471 |
perinuclear region of cytoplasm |
|
GO:0050729 |
positive regulation of inflammatory response |
|
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
|
GO:0050829 |
defense response to Gram-negative bacterium |
|
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
|
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
|
GO:0051930 |
regulation of sensory perception of pain |
|
GO:0052033 |
pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity |
|
GO:0060729 |
intestinal epithelial structure maintenance |
|
GO:0060907 |
positive regulation of macrophage cytokine production |
|
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
|
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
|
GO:0070430 |
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway |
|
GO:0070434 |
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
|
GO:0070542 |
response to fatty acid |
|
GO:0071222 |
cellular response to lipopolysaccharide |
|
GO:0071223 |
cellular response to lipoteichoic acid |
|
GO:0071260 |
cellular response to mechanical stimulus |
