Gene basic information
| LiverAtlas Gene ID |
HuLG004906 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TNF |
|
Synonyms |
DIF|TNFNalpha|TNFA|TNFSF2 |
|
Gene name |
tumor necrosis factor |
|
Gene Type |
protein-coding |
|
Chromosome |
6 |
|
Genomics Location |
6p21.3 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:11892
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000060 |
protein import into nucleus, translocation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0000185 |
activation of MAPKKK activity |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0001666 |
response to hypoxia |
|
GO:0001775 |
cell activation |
|
GO:0001819 |
positive regulation of cytokine production |
|
GO:0001891 |
phagocytic cup |
|
GO:0001934 |
positive regulation of protein phosphorylation |
|
GO:0002020 |
protease binding |
|
GO:0002037 |
negative regulation of L-glutamate transport |
|
GO:0002439 |
chronic inflammatory response to antigenic stimulus |
|
GO:0002740 |
negative regulation of cytokine secretion involved in immune response |
|
GO:0002876 |
positive regulation of chronic inflammatory response to antigenic stimulus |
|
GO:0002925 |
positive regulation of humoral immune response mediated by circulating immunoglobulin |
|
GO:0003009 |
skeletal muscle contraction |
|
GO:0005125 |
cytokine activity |
|
GO:0005164 |
tumor necrosis factor receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005622 |
intracellular |
|
GO:0005886 |
plasma membrane |
|
GO:0005887 |
integral to plasma membrane |
|
GO:0006006 |
glucose metabolic process |
|
GO:0006915 |
apoptosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0006927 |
transformed cell apoptosis |
|
GO:0006954 |
inflammatory response |
|
GO:0006959 |
humoral immune response |
|
GO:0007165 |
signal transduction |
|
GO:0007275 |
multicellular organismal development |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008624 |
induction of apoptosis by extracellular signals |
|
GO:0008625 |
induction of apoptosis via death domain receptors |
|
GO:0009612 |
response to mechanical stimulus |
|
GO:0009615 |
response to virus |
|
GO:0009651 |
response to salt stress |
|
GO:0009887 |
organ morphogenesis |
|
GO:0009897 |
external side of plasma membrane |
|
GO:0009986 |
cell surface |
|
GO:0010888 |
negative regulation of lipid storage |
|
GO:0010940 |
positive regulation of necrotic cell death |
|
GO:0014823 |
response to activity |
|
GO:0019722 |
calcium-mediated signaling |
|
GO:0030198 |
extracellular matrix organization |
|
GO:0030730 |
sequestering of triglyceride |
|
GO:0031334 |
positive regulation of protein complex assembly |
|
GO:0031622 |
positive regulation of fever generation |
|
GO:0032715 |
negative regulation of interleukin-6 production |
|
GO:0032722 |
positive regulation of chemokine production |
|
GO:0032729 |
positive regulation of interferon-gamma production |
|
GO:0032755 |
positive regulation of interleukin-6 production |
|
GO:0032800 |
receptor biosynthetic process |
|
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
|
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
|
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
|
GO:0042346 |
positive regulation of NF-kappaB import into nucleus |
|
GO:0042493 |
response to drug |
|
GO:0042802 |
identical protein binding |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0043243 |
positive regulation of protein complex disassembly |
|
GO:0043406 |
positive regulation of MAP kinase activity |
|
GO:0043525 |
positive regulation of neuron apoptosis |
|
GO:0044130 |
negative regulation of growth of symbiont in host |
|
GO:0045071 |
negative regulation of viral genome replication |
|
GO:0045080 |
positive regulation of chemokine biosynthetic process |
|
GO:0045121 |
membrane raft |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045599 |
negative regulation of fat cell differentiation |
|
GO:0045672 |
positive regulation of osteoclast differentiation |
|
GO:0045840 |
positive regulation of mitosis |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0045994 |
positive regulation of translational initiation by iron |
|
GO:0046325 |
negative regulation of glucose import |
|
GO:0046330 |
positive regulation of JNK cascade |
|
GO:0048566 |
embryonic digestive tract development |
|
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
|
GO:0050715 |
positive regulation of cytokine secretion |
|
GO:0050796 |
regulation of insulin secretion |
|
GO:0050806 |
positive regulation of synaptic transmission |
|
GO:0050830 |
defense response to Gram-positive bacterium |
|
GO:0050901 |
leukocyte tethering or rolling |
|
GO:0050995 |
negative regulation of lipid catabolic process |
|
GO:0051023 |
regulation of immunoglobulin secretion |
|
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
|
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
|
GO:0051222 |
positive regulation of protein transport |
|
GO:0051384 |
response to glucocorticoid stimulus |
|
GO:0051533 |
positive regulation of NFAT protein import into nucleus |
|
GO:0051798 |
positive regulation of hair follicle development |
|
GO:0055037 |
recycling endosome |
|
GO:0060555 |
induction of necroptosis by extracellular signals |
|
GO:0060557 |
positive regulation of vitamin D biosynthetic process |
|
GO:0060559 |
positive regulation of calcidiol 1-monooxygenase activity |
|
GO:0060664 |
epithelial cell proliferation involved in salivary gland morphogenesis |
|
GO:0060693 |
regulation of branching involved in salivary gland morphogenesis |
|
GO:0061048 |
negative regulation of branching involved in lung morphogenesis |
|
GO:0070265 |
necrotic cell death |
|
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
|
GO:0071316 |
cellular response to nicotine |
|
GO:0071803 |
positive regulation of podosome assembly |
