Gene basic information
| LiverAtlas Gene ID |
HuLG004931 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TP53 |
|
Synonyms |
FLJ92943|LFS1|P53|TRP53 |
|
Gene name |
tumor protein p53 |
|
Gene Type |
protein-coding |
|
Chromosome |
17 |
|
Genomics Location |
17p13.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:11998
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0000733 |
DNA strand renaturation |
|
GO:0000739 |
DNA strand annealing activity |
|
GO:0000785 |
chromatin |
|
GO:0000790 |
nuclear chromatin |
|
GO:0001085 |
RNA polymerase II transcription factor binding |
|
GO:0002020 |
protease binding |
|
GO:0002039 |
p53 binding |
|
GO:0003677 |
DNA binding |
|
GO:0003682 |
chromatin binding |
|
GO:0003684 |
damaged DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0005507 |
copper ion binding |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005626 |
insoluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005657 |
replication fork |
|
GO:0005669 |
transcription factor TFIID complex |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005829 |
cytosol |
|
GO:0006284 |
base-excision repair |
|
GO:0006289 |
nucleotide-excision repair |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006461 |
protein complex assembly |
|
GO:0006915 |
apoptosis |
|
GO:0006974 |
response to DNA damage stimulus |
|
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
|
GO:0006978 |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
|
GO:0006983 |
ER overload response |
|
GO:0007049 |
cell cycle |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0007275 |
multicellular organismal development |
|
GO:0007569 |
cell aging |
|
GO:0007596 |
blood coagulation |
|
GO:0008104 |
protein localization |
|
GO:0008134 |
transcription factor binding |
|
GO:0008270 |
zinc ion binding |
|
GO:0008283 |
cell proliferation |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008340 |
determination of adult lifespan |
|
GO:0008629 |
induction of apoptosis by intracellular signals |
|
GO:0008635 |
activation of caspase activity by cytochrome c |
|
GO:0010165 |
response to X-ray |
|
GO:0010332 |
response to gamma radiation |
|
GO:0016363 |
nuclear matrix |
|
GO:0016604 |
nuclear body |
|
GO:0016605 |
PML body |
|
GO:0019899 |
enzyme binding |
|
GO:0019901 |
protein kinase binding |
|
GO:0030154 |
cell differentiation |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
|
GO:0031065 |
positive regulation of histone deacetylation |
|
GO:0031571 |
mitotic cell cycle G1/S transition DNA damage checkpoint |
|
GO:0031625 |
ubiquitin protein ligase binding |
|
GO:0034613 |
cellular protein localization |
|
GO:0034644 |
cellular response to UV |
|
GO:0035035 |
histone acetyltransferase binding |
|
GO:0035690 |
cellular response to drug |
|
GO:0042149 |
cellular response to glucose starvation |
|
GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
|
GO:0042981 |
regulation of apoptosis |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043234 |
protein complex |
|
GO:0043525 |
positive regulation of neuron apoptosis |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046677 |
response to antibiotic |
|
GO:0046872 |
metal ion binding |
|
GO:0046902 |
regulation of mitochondrial membrane permeability |
|
GO:0046982 |
protein heterodimerization activity |
|
GO:0047485 |
protein N-terminus binding |
|
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
|
GO:0051087 |
chaperone binding |
|
GO:0051097 |
negative regulation of helicase activity |
|
GO:0051262 |
protein tetramerization |
|
GO:0051721 |
protein phosphatase 2A binding |
|
GO:0070245 |
positive regulation of thymocyte apoptosis |
|
GO:0071456 |
cellular response to hypoxia |
|
GO:0071479 |
cellular response to ionizing radiation |
|
GO:0072332 |
signal transduction by p53 class mediator resulting in induction of apoptosis |
|
GO:0090399 |
replicative senescence |
|
GO:0090403 |
oxidative stress-induced premature senescence |
|
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
