Gene basic information
| LiverAtlas Gene ID |
HuLG004958 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TRAF3 |
|
Synonyms |
CAPN1|CD40bp|CRAF1|LAP1 |
|
Gene name |
TNF receptor-associated factor 3 |
|
Gene Type |
protein-coding |
|
Chromosome |
14 |
|
Genomics Location |
14q32.32 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:12033
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001817 |
regulation of cytokine production |
|
GO:0002224 |
toll-like receptor signaling pathway |
|
GO:0004842 |
ubiquitin-protein ligase activity |
|
GO:0004871 |
signal transducer activity |
|
GO:0005515 |
protein binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005768 |
endosome |
|
GO:0005829 |
cytosol |
|
GO:0006917 |
induction of apoptosis |
|
GO:0007165 |
signal transduction |
|
GO:0008270 |
zinc ion binding |
|
GO:0009898 |
internal side of plasma membrane |
|
GO:0016874 |
ligase activity |
|
GO:0019901 |
protein kinase binding |
|
GO:0030162 |
regulation of proteolysis |
|
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
|
GO:0032480 |
negative regulation of type I interferon production |
|
GO:0032648 |
regulation of interferon-beta production |
|
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
|
GO:0035631 |
CD40 receptor complex |
|
GO:0042981 |
regulation of apoptosis |
|
GO:0046872 |
metal ion binding |
|
GO:0050688 |
regulation of defense response to virus |
