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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG005015

Entrez Gene ID

7298

Official Gene Symbol

TYMS

Synonyms

HST422|MGC88736|TMS|TS

Gene name

thymidylate synthetase

Gene Type

protein-coding

Chromosome

18

Genomics Location

18p11.32

Known cancer genes

Yes

Protein products

Thymidylate synthase

Thymidylate synthase

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:12441
MIM:188350
Ensembl:ENSG00000176890
HPRD:01774
RefSeq Genomic nucleotide accession:AC_000061
RefSeq Genomic nucleotide gi:89161196

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000082

G1/S transition of mitotic cell cycle

GO:0000083

regulation of transcription involved in G1/S phase of mitotic cell cycle

GO:0000166

nucleotide binding

GO:0000278

mitotic cell cycle

GO:0004799

thymidylate synthase activity

GO:0005542

folic acid binding

GO:0005625

soluble fraction

GO:0005829

cytosol

GO:0006139

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO:0006206

pyrimidine base metabolic process

GO:0006231

dTMP biosynthetic process

GO:0006260

DNA replication

GO:0006281

DNA repair

GO:0007568

aging

GO:0008168

methyltransferase activity

GO:0009157

deoxyribonucleoside monophosphate biosynthetic process

GO:0009165

nucleotide biosynthetic process

GO:0016740

transferase activity

GO:0019088

immortalization of host cell by virus

GO:0031100

organ regeneration

GO:0042493

response to drug

GO:0046078

dUMP metabolic process

GO:0046134

pyrimidine nucleoside biosynthetic process

GO:0046683

response to organophosphorus

GO:0048015

phosphatidylinositol-mediated signaling

GO:0048037

cofactor binding

GO:0048589

developmental growth

GO:0051216

cartilage development

GO:0051384

response to glucocorticoid stimulus

GO:0055086

nucleobase, nucleoside and nucleotide metabolic process

GO:0060574

intestinal epithelial cell maturation