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Gene basic information

LiverAtlas Gene ID

HuLG005046

Entrez Gene ID

7345

Official Gene Symbol

UCHL1

Synonyms

PARK5|PGP_9.5|PGP9.5|PGP95|UchNL1

Gene name

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Gene Type

protein-coding

Chromosome

4

Genomics Location

4p14

Known cancer genes

Yes

Protein products

Ubiquitin carboxyl-terminal esterase L1 (Ubiquitin thiolesterase), isoform CRA a

Ubiquitin carboxyl-terminal hydrolase isozyme L1

Related liver disease name

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:12513
MIM:191342
Ensembl:ENSG00000154277
HPRD:01877
RefSeq Genomic nucleotide accession:AC_000047
RefSeq Genomic nucleotide gi:89161206

 

Ontology annotation

GO ID

GO annotation

GO:0004197

cysteine-type endopeptidase activity

GO:0004221

ubiquitin thiolesterase activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0006511

ubiquitin-dependent protein catabolic process

GO:0006950

response to stress

GO:0007412

axon target recognition

GO:0007628

adult walking behavior

GO:0008219

cell death

GO:0008233

peptidase activity

GO:0008242

omega peptidase activity

GO:0008283

cell proliferation

GO:0016579

protein deubiquitination

GO:0016874

ligase activity

GO:0019896

axon transport of mitochondrion

GO:0030424

axon

GO:0031694

alpha-2A adrenergic receptor binding

GO:0042755

eating behavior

GO:0043025

neuronal cell body

GO:0043130

ubiquitin binding

GO:0043231

intracellular membrane-bounded organelle

GO:0043407

negative regulation of MAP kinase activity

GO:0050905

neuromuscular process