HuLG005102

Entrez Gene ID

7421

Official Gene Symbol

VDR

Synonyms

NR1I1

Gene name

vitamin D (1,25- dihydroxyvitamin D3) receptor

Gene Type

protein-coding

Chromosome

12

Genomics Location

12q13.11

Known cancer genes

Yes

Protein products

Vitamin D nuclear receptor variant 1

Vitamin D3 receptor

Related liver disease name

Hepatitis B

Chronic hepatitis B

Hepatitis C

Alcoholic liver cirrhosis

Biliary cirrhosis

Primary biliary cirrhosis

Database cross reference

HGNC:12679
MIM:601769
Ensembl:ENSG00000111424
HPRD:03463
RefSeq Genomic nucleotide accession:AC_000055
RefSeq Genomic nucleotide gi:89161189

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001501

skeletal system development

GO:0003677

DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003707

steroid hormone receptor activity

GO:0005499

vitamin D binding

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005720

nuclear heterochromatin

GO:0006351

transcription, DNA-dependent

GO:0006816

calcium ion transport

GO:0006874

cellular calcium ion homeostasis

GO:0007165

signal transduction

GO:0007275

multicellular organismal development

GO:0007595

lactation

GO:0008270

zinc ion binding

GO:0008285

negative regulation of cell proliferation

GO:0008434

vitamin D3 receptor activity

GO:0008628

induction of apoptosis by hormones

GO:0009887

organ morphogenesis

GO:0010467

gene expression

GO:0010980

positive regulation of vitamin D 24-hydroxylase activity

GO:0034339

regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

GO:0043565

sequence-specific DNA binding

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0046697

decidualization

GO:0046872

metal ion binding

GO:0046965

retinoid X receptor binding

GO:0050892

intestinal absorption

GO:0060058

positive regulation of apoptosis involved in mammary gland involution

GO:0060558

regulation of calcidiol 1-monooxygenase activity

GO:0060745

mammary gland branching involved in pregnancy

GO:0070561

vitamin D receptor signaling pathway

GO:0070644

vitamin D response element binding