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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG005108

Entrez Gene ID

7429

Official Gene Symbol

VIL1

Synonyms

D2S1471|VIL

Gene name

villin 1

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q35

Known cancer genes

Yes

Protein products

Villin 1 variant

Villin-1

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:12690
MIM:193040
Ensembl:ENSG00000127831
HPRD:01898
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001726

ruffle

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005546

phosphatidylinositol-4,5-bisphosphate binding

GO:0005737

cytoplasm

GO:0005856

cytoskeleton

GO:0005902

microvillus

GO:0006461

protein complex assembly

GO:0006915

apoptosis

GO:0007010

cytoskeleton organization

GO:0007173

epidermal growth factor receptor signaling pathway

GO:0008360

regulation of cell shape

GO:0009617

response to bacterium

GO:0010634

positive regulation of epithelial cell migration

GO:0030027

lamellipodium

GO:0030041

actin filament polymerization

GO:0030042

actin filament depolymerization

GO:0030175

filopodium

GO:0030335

positive regulation of cell migration

GO:0032233

positive regulation of actin filament bundle assembly

GO:0032432

actin filament bundle

GO:0032433

filopodium tip

GO:0035727

lysophosphatidic acid binding

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

GO:0043027

caspase inhibitor activity

GO:0043154

negative regulation of caspase activity

GO:0043231

intracellular membrane-bounded organelle

GO:0051014

actin filament severing

GO:0051015

actin filament binding

GO:0051125

regulation of actin nucleation

GO:0051693

actin filament capping

GO:0060327

cytoplasmic actin-based contraction involved in cell motility

GO:0061041

regulation of wound healing

GO:0071364

cellular response to epidermal growth factor stimulus

GO:2000392

regulation of lamellipodium morphogenesis