HuLG005135

Entrez Gene ID

7472

Official Gene Symbol

WNT2

Synonyms

INT1L1|IRP

Gene name

wingless-type MMTV integration site family member 2

Gene Type

protein-coding

Chromosome

7

Genomics Location

7q31.2

Known cancer genes

Yes

Protein products

Protein Wnt

Protein Wnt-2

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:12780
MIM:147870
Ensembl:ENSG00000105989
HPRD:00999
RefSeq Genomic nucleotide accession:AC_000050
RefSeq Genomic nucleotide gi:89161211

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0001938

positive regulation of endothelial cell proliferation

GO:0002053

positive regulation of mesenchymal cell proliferation

GO:0002088

lens development in camera-type eye

GO:0004871

signal transducer activity

GO:0005109

frizzled binding

GO:0005110

frizzled-2 binding

GO:0005125

cytokine activity

GO:0005576

extracellular region

GO:0005578

proteinaceous extracellular matrix

GO:0005615

extracellular space

GO:0005737

cytoplasm

GO:0005886

plasma membrane

GO:0007223

Wnt receptor signaling pathway, calcium modulating pathway

GO:0007267

cell-cell signaling

GO:0007275

multicellular organismal development

GO:0008284

positive regulation of cell proliferation

GO:0009950

dorsal/ventral axis specification

GO:0016055

Wnt receptor signaling pathway

GO:0030182

neuron differentiation

GO:0030324

lung development

GO:0031012

extracellular matrix

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0048146

positive regulation of fibroblast proliferation

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

GO:0055009

atrial cardiac muscle tissue morphogenesis

GO:0060045

positive regulation of cardiac muscle cell proliferation

GO:0060070

canonical Wnt receptor signaling pathway

GO:0060317

cardiac epithelial to mesenchymal transition

GO:0060492

lung induction

GO:0060501

positive regulation of epithelial cell proliferation involved in lung morphogenesis

GO:0060716

labyrinthine layer blood vessel development

GO:0061072

iris morphogenesis

GO:0061180

mammary gland epithelium development

GO:0071300

cellular response to retinoic acid

GO:0071560

cellular response to transforming growth factor beta stimulus

GO:0090263

positive regulation of canonical Wnt receptor signaling pathway