Gene basic information
| LiverAtlas Gene ID |
HuLG005148 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
WRN |
|
Synonyms |
DKFZp686C2056|RECQ3|RECQL2|RECQL3 |
|
Gene name |
Werner syndrome, RecQ helicase-like |
|
Gene Type |
protein-coding |
|
Chromosome |
8 |
|
Genomics Location |
8p12 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Database cross reference |
HGNC:12791
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0000287 |
magnesium ion binding |
|
GO:0000403 |
Y-form DNA binding |
|
GO:0000405 |
bubble DNA binding |
|
GO:0000723 |
telomere maintenance |
|
GO:0000731 |
DNA synthesis involved in DNA repair |
|
GO:0001302 |
replicative cell aging |
|
GO:0003677 |
DNA binding |
|
GO:0003678 |
DNA helicase activity |
|
GO:0004003 |
ATP-dependent DNA helicase activity |
|
GO:0004386 |
helicase activity |
|
GO:0004527 |
exonuclease activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005730 |
nucleolus |
|
GO:0005813 |
centrosome |
|
GO:0006139 |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
GO:0006200 |
ATP catabolic process |
|
GO:0006259 |
DNA metabolic process |
|
GO:0006260 |
DNA replication |
|
GO:0006284 |
base-excision repair |
|
GO:0006310 |
DNA recombination |
|
GO:0006974 |
response to DNA damage stimulus |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007568 |
aging |
|
GO:0007569 |
cell aging |
|
GO:0008408 |
3'-5' exonuclease activity |
|
GO:0009267 |
cellular response to starvation |
|
GO:0009378 |
four-way junction helicase activity |
|
GO:0010225 |
response to UV-C |
|
GO:0010259 |
multicellular organismal aging |
|
GO:0016887 |
ATPase activity |
|
GO:0030145 |
manganese ion binding |
|
GO:0031297 |
replication fork processing |
|
GO:0032066 |
nucleolus to nucleoplasm transport |
|
GO:0032389 |
MutLalpha complex |
|
GO:0032403 |
protein complex binding |
|
GO:0040009 |
regulation of growth rate |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0042981 |
regulation of apoptosis |
|
GO:0043138 |
3'-5' DNA helicase activity |
|
GO:0043140 |
ATP-dependent 3'-5' DNA helicase activity |
|
GO:0044237 |
cellular metabolic process |
|
GO:0051345 |
positive regulation of hydrolase activity |
|
GO:0051880 |
G-quadruplex DNA binding |
