HuLG005463

Entrez Gene ID

8313

Official Gene Symbol

AXIN2

Synonyms

AXIL|DKFZp781B0869|MGC10366|MGC126582

Gene name

axin 2

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q23-q24

Known cancer genes

Yes

Protein products

Axin-2

Putative uncharacterized protein DKFZp781B0869

AXIN2 protein

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:904
MIM:604025
Ensembl:ENSG00000168646
HPRD:04935
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

GO annotation

GO:0001934

positive regulation of protein phosphorylation

GO:0001957

intramembranous ossification

GO:0003413

chondrocyte differentiation involved in endochondral bone morphogenesis

GO:0004871

signal transducer activity

GO:0005096

GTPase activator activity

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005813

centrosome

GO:0005881

cytoplasmic microtubule

GO:0005886

plasma membrane

GO:0005938

cell cortex

GO:0007275

multicellular organismal development

GO:0008013

beta-catenin binding

GO:0008285

negative regulation of cell proliferation

GO:0009950

dorsal/ventral axis specification

GO:0010718

positive regulation of epithelial to mesenchymal transition

GO:0010942

positive regulation of cell death

GO:0014069

postsynaptic density

GO:0016023

cytoplasmic membrane-bounded vesicle

GO:0019899

enzyme binding

GO:0019901

protein kinase binding

GO:0030111

regulation of Wnt receptor signaling pathway

GO:0030282

bone mineralization

GO:0031625

ubiquitin protein ligase binding

GO:0032423

regulation of mismatch repair

GO:0034613

cellular protein localization

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

GO:0035414

negative regulation of catenin import into nucleus

GO:0042476

odontogenesis

GO:0043547

positive regulation of GTPase activity

GO:0043570

maintenance of DNA repeat elements

GO:0045668

negative regulation of osteoblast differentiation

GO:0045860

positive regulation of protein kinase activity

GO:0048255

mRNA stabilization

GO:0061181

regulation of chondrocyte development

GO:0070016

armadillo repeat domain binding

GO:0070411

I-SMAD binding

GO:0070602

regulation of centromeric sister chromatid cohesion

GO:0071407

cellular response to organic cyclic compound

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

GO:0090244

Wnt receptor signaling pathway involved in somitogenesis

GO:2000054

negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification