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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG005714

Entrez Gene ID

8647

Official Gene Symbol

ABCB11

Synonyms

ABC16|BRIC2|BSEP|PFICN2|PFIC2|PGY4|SPGP

Gene name

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q24

Known cancer genes

Yes

Protein products

Bile salt export pump

Putative uncharacterized protein ABCB11

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Biliary cirrhosis

Hepatocellular carcinoma

Primary biliary cirrhosis

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Primary sclerosing cholangitis

Database cross reference

HGNC:42
MIM:603201
Ensembl:ENSG00000073734
HPRD:04436
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000139

Golgi membrane

GO:0000166

nucleotide binding

GO:0005215

transporter activity

GO:0005524

ATP binding

GO:0005624

membrane fraction

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006699

bile acid biosynthetic process

GO:0006810

transport

GO:0008206

bile acid metabolic process

GO:0008554

sodium-exporting ATPase activity, phosphorylative mechanism

GO:0015126

canalicular bile acid transmembrane transporter activity

GO:0015432

bile acid-exporting ATPase activity

GO:0015721

bile acid and bile salt transport

GO:0015722

canalicular bile acid transport

GO:0016021

integral to membrane

GO:0016324

apical plasma membrane

GO:0016887

ATPase activity

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO:0046581

intercellular canaliculus

GO:0055085

transmembrane transport