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Gene basic information

LiverAtlas Gene ID

HuLG005720

Entrez Gene ID

8654

Official Gene Symbol

PDE5A

Synonyms

CGBNPDE|CN5A|PDE5

Gene name

phosphodiesterase 5A, cGMP-specific

Gene Type

protein-coding

Chromosome

4

Genomics Location

4q27

Protein products

cGMP-specific 3',5'-cyclic phosphodiesterase

Putative uncharacterized protein PDE5A

CGMP-specific phosphodiesterase PDE5A2

CGMP-specific phosphodiesterase PDE5A1

CGMP-specific phosphodiesterase PDE5A1

Related liver disease name

Liver fibrosis and liver cirrhosis

Database cross reference

HGNC:8784
MIM:603310
Ensembl:ENSG00000138735
HPRD:04497
RefSeq Genomic nucleotide accession:AC_000047
RefSeq Genomic nucleotide gi:89161206

 

Ontology annotation

GO ID

GO annotation

GO:0000166

nucleotide binding

GO:0001666

response to hypoxia

GO:0002026

regulation of the force of heart contraction

GO:0002678

positive regulation of chronic inflammatory response

GO:0004114

3',5'-cyclic-nucleotide phosphodiesterase activity

GO:0005575

cellular component

GO:0005829

cytosol

GO:0007165

signal transduction

GO:0007399

nervous system development

GO:0007596

blood coagulation

GO:0007614

short-term memory

GO:0008270

zinc ion binding

GO:0009187

cyclic nucleotide metabolic process

GO:0010613

positive regulation of cardiac muscle hypertrophy

GO:0016787

hydrolase activity

GO:0030168

platelet activation

GO:0030553

cGMP binding

GO:0032496

response to lipopolysaccharide

GO:0033574

response to testosterone stimulus

GO:0042130

negative regulation of T cell proliferation

GO:0042311

vasodilation

GO:0043065

positive regulation of apoptosis

GO:0043406

positive regulation of MAP kinase activity

GO:0045907

positive regulation of vasoconstriction

GO:0046069

cGMP catabolic process

GO:0046872

metal ion binding

GO:0047555

3',5'-cyclic-GMP phosphodiesterase activity

GO:0055119

relaxation of cardiac muscle

GO:0060282

positive regulation of oocyte development