Gene basic information
LiverAtlas Gene ID |
HuLG005790 |
Entrez Gene ID |
|
Official Gene Symbol |
TNFSF10 |
Synonyms |
APO2L|ApoN2L|CD253|TL2|TRAIL |
Gene name |
tumor necrosis factor (ligand) superfamily, member 10 |
Gene Type |
protein-coding |
Chromosome |
3 |
Genomics Location |
3q26 |
Known cancer genes |
Yes |
Protein products |
Tumor necrosis factor apoptosis-inducing ligand splice variant delta |
Related liver disease name |
|
Database cross reference |
HGNC:11925
|
Liver relevance
HCC significant genes |
Yes/No |
Yes |
Evidence |
EHCO HCC.net OncoDB |
|
Quality score |
|
Ontology annotation
GO ID |
GO annotation |
GO:0005102 |
receptor binding |
GO:0005125 |
cytokine activity |
GO:0005164 |
tumor necrosis factor receptor binding |
GO:0005515 |
protein binding |
GO:0005576 |
extracellular region |
GO:0005615 |
extracellular space |
GO:0005625 |
soluble fraction |
GO:0005887 |
integral to plasma membrane |
GO:0006915 |
apoptosis |
GO:0006917 |
induction of apoptosis |
GO:0006919 |
activation of caspase activity |
GO:0006955 |
immune response |
GO:0007165 |
signal transduction |
GO:0007267 |
cell-cell signaling |
GO:0008624 |
induction of apoptosis by extracellular signals |
GO:0008633 |
activation of pro-apoptotic gene products |
GO:0016020 |
membrane |
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
GO:0046872 |
metal ion binding |