Gene basic information
| LiverAtlas Gene ID |
HuLG005824 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
TNFRSF10B |
|
Synonyms |
CD262|DR5|KILLER|KILLER/DR5|TRAILNR2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9 |
|
Gene name |
tumor necrosis factor receptor superfamily, member 10b |
|
Gene Type |
protein-coding |
|
Chromosome |
8 |
|
Genomics Location |
8p22-p21 |
|
Known cancer genes |
Yes |
|
Protein products |
Tumor necrosis factor receptor superfamily member 10B Tumor necrosis factor receptor superfamily, member 10b |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:11905
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0004872 |
receptor activity |
|
GO:0005515 |
protein binding |
|
GO:0005886 |
plasma membrane |
|
GO:0006915 |
apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0007166 |
cell surface receptor linked signaling pathway |
|
GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
|
GO:0008624 |
induction of apoptosis by extracellular signals |
|
GO:0008625 |
induction of apoptosis via death domain receptors |
|
GO:0008633 |
activation of pro-apoptotic gene products |
|
GO:0008656 |
caspase activator activity |
|
GO:0016021 |
integral to membrane |
|
GO:0042981 |
regulation of apoptosis |
|
GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0045569 |
TRAIL binding |
|
GO:0071260 |
cellular response to mechanical stimulus |
