HuLG005862

Entrez Gene ID

8837

Official Gene Symbol

CFLAR

Synonyms

CASH|CASP8AP1|CLARP|Casper|FLAME|FLAMEN1|FLAME1|FLIP|INFLICE|MRIT|cNFLIP|cNFLIPL|cNFLIPR|cNFLIPS

Gene name

CASP8 and FADD-like apoptosis regulator

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q33-q34

Known cancer genes

Yes

Protein products

cDNA FLJ58399, highly similar to CASP8 and FADD-like apoptosis regulator

cDNA FLJ59611, highly similar to CASP8 and FADD-like apoptosis regulator

CASP8 and FADD-like apoptosis regulator

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:1876
MIM:603599
Ensembl:ENSG00000003402
HPRD:04671
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0004197

cysteine-type endopeptidase activity

GO:0005515

protein binding

GO:0005737

cytoplasm

GO:0006508

proteolysis

GO:0006916

anti-apoptosis

GO:0008624

induction of apoptosis by extracellular signals

GO:0031265

CD95 death-inducing signaling complex

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

GO:0043154

negative regulation of caspase activity

GO:0044419

interspecies interaction between organisms