HuLG005878

Entrez Gene ID

8856

Official Gene Symbol

NR1I2

Synonyms

BXR|ONR1|PAR|PAR1|PAR2|PARq|PRR|PXR|SAR|SXR

Gene name

nuclear receptor subfamily 1, group I, member 2

Gene Type

protein-coding

Chromosome

3

Genomics Location

3q12-q13.3

Known cancer genes

Yes

Protein products

Nuclear receptor subfamily 1, group I, member 2, isoform CRA b

Nuclear receptor subfamily 1 group I member 2

Related liver disease name

Liver fibrosis and liver cirrhosis

Biliary cirrhosis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:7968
MIM:603065
Ensembl:ENSG00000144852
HPRD:04346
RefSeq Genomic nucleotide accession:AC_000046
RefSeq Genomic nucleotide gi:89161204

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003707

steroid hormone receptor activity

GO:0003713

transcription coactivator activity

GO:0004879

ligand-dependent nuclear receptor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0006805

xenobiotic metabolic process

GO:0007165

signal transduction

GO:0008144

drug binding

GO:0008202

steroid metabolic process

GO:0008270

zinc ion binding

GO:0010467

gene expression

GO:0034339

regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

GO:0042738

exogenous drug catabolic process

GO:0042908

xenobiotic transport

GO:0043565

sequence-specific DNA binding

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0046618

drug export

GO:0046872

metal ion binding