Gene basic information
| LiverAtlas Gene ID |
HuLG005894 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SQSTM1 |
|
Synonyms |
A170|OSIL|PDB3|ZIP3|p60|p62|p62B |
|
Gene name |
sequestosome 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
5 |
|
Genomics Location |
5q35 |
|
Known cancer genes |
Yes |
|
Protein products |
Phosphotyrosine independent ligand p62B for the Lck SH2 domain B-cell isoform |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:11280
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0005080 |
protein kinase C binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005737 |
cytoplasm |
|
GO:0005770 |
late endosome |
|
GO:0005829 |
cytosol |
|
GO:0006511 |
ubiquitin-dependent protein catabolic process |
|
GO:0006914 |
autophagy |
|
GO:0006915 |
apoptosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006950 |
response to stress |
|
GO:0008104 |
protein localization |
|
GO:0008270 |
zinc ion binding |
|
GO:0008624 |
induction of apoptosis by extracellular signals |
|
GO:0016197 |
endosome transport |
|
GO:0016236 |
macroautophagy |
|
GO:0019901 |
protein kinase binding |
|
GO:0030154 |
cell differentiation |
|
GO:0030971 |
receptor tyrosine kinase binding |
|
GO:0035556 |
intracellular signal transduction |
|
GO:0042169 |
SH2 domain binding |
|
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB cascade |
|
GO:0043130 |
ubiquitin binding |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046872 |
metal ion binding |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
