HuLG006041

Entrez Gene ID

9101

Official Gene Symbol

USP8

Synonyms

FLJ34456|HumORF8|KIAA0055|MGC129718|UBPY

Gene name

ubiquitin specific peptidase 8

Gene Type

protein-coding

Chromosome

15

Genomics Location

15q21.2

Known cancer genes

Yes

Protein products

cDNA FLJ34456 fis, clone HLUNG2002659, highly similar to Ubiquitin carboxyl-terminal hydrolase 8 (EC3.1.2.15)

USP8 protein

USP8 protein

Ubiquitin carboxyl-terminal hydrolase 8

Database cross reference

HGNC:12631
MIM:603158
Ensembl:ENSG00000138592
HPRD:04405
RefSeq Genomic nucleotide accession:AC_000058
RefSeq Genomic nucleotide gi:89161193

GO annotation

GO:0004197

cysteine-type endopeptidase activity

GO:0004221

ubiquitin thiolesterase activity

GO:0004843

ubiquitin-specific protease activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005769

early endosome

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0006511

ubiquitin-dependent protein catabolic process

GO:0007032

endosome organization

GO:0007049

cell cycle

GO:0007265

Ras protein signal transduction

GO:0008233

peptidase activity

GO:0008283

cell proliferation

GO:0017124

SH3 domain binding

GO:0019897

extrinsic to plasma membrane

GO:0031313

extrinsic to endosome membrane

GO:0070536

protein K63-linked deubiquitination

GO:0071108

protein K48-linked deubiquitination