HuLG006100

Entrez Gene ID

9181

Official Gene Symbol

ARHGEF2

Synonyms

DKFZp547L106|DKFZp547P1516|FLJ45440|GEF|GEFNH1|GEFH1|KIAA0651|LFP40|P40

Gene name

Rho/Rac guanine nucleotide exchange factor (GEF) 2

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q21-q22

Known cancer genes

Yes

Protein products

Rho guanine nucleotide exchange factor 2

Database cross reference

HGNC:682
MIM:607560
Ensembl:ENSG00000116584
HPRD:10458
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

GO annotation

GO:0000902

cell morphogenesis

GO:0005085

guanyl-nucleotide exchange factor activity

GO:0005089

Rho guanyl-nucleotide exchange factor activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005737

cytoplasm

GO:0005794

Golgi apparatus

GO:0005819

spindle

GO:0005829

cytosol

GO:0005856

cytoskeleton

GO:0005874

microtubule

GO:0005886

plasma membrane

GO:0005923

tight junction

GO:0006886

intracellular protein transport

GO:0006915

apoptosis

GO:0007015

actin filament organization

GO:0007026

negative regulation of microtubule depolymerization

GO:0007049

cell cycle

GO:0007067

mitosis

GO:0007264

small GTPase mediated signal transduction

GO:0008017

microtubule binding

GO:0008270

zinc ion binding

GO:0008624

induction of apoptosis by extracellular signals

GO:0017048

Rho GTPase binding

GO:0030054

cell junction

GO:0030676

Rac guanyl-nucleotide exchange factor activity

GO:0032587

ruffle membrane

GO:0035023

regulation of Rho protein signal transduction

GO:0042127

regulation of cell proliferation

GO:0042995

cell projection

GO:0046872

metal ion binding

GO:0048011

nerve growth factor receptor signaling pathway

GO:0048365

Rac GTPase binding

GO:0051056

regulation of small GTPase mediated signal transduction

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051301

cell division