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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG006727

Entrez Gene ID

9971

Official Gene Symbol

NR1H4

Synonyms

BAR|FXR|HRRN1|HRR1|MGC163445|RIP14

Gene name

nuclear receptor subfamily 1, group H, member 4

Gene Type

protein-coding

Chromosome

12

Genomics Location

12q23.1

Known cancer genes

Yes

Protein products

Farnesoid X receptor

Farnesoid X nuclear receptor

Bile acid receptor

NR1H4 protein

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:7967
MIM:603826
Ensembl:ENSG00000012504
HPRD:04827
RefSeq Genomic nucleotide accession:AC_000055
RefSeq Genomic nucleotide gi:89161189

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0003707

steroid hormone receptor activity

GO:0003713

transcription coactivator activity

GO:0003714

transcription corepressor activity

GO:0004879

ligand-dependent nuclear receptor activity

GO:0004887

thyroid hormone receptor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0006351

transcription, DNA-dependent

GO:0006355

regulation of transcription, DNA-dependent

GO:0007165

signal transduction

GO:0008206

bile acid metabolic process

GO:0008270

zinc ion binding

GO:0010467

gene expression

GO:0034339

regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

GO:0043565

sequence-specific DNA binding

GO:0046872

metal ion binding