HuLG006960

Entrez Gene ID

10252

Official Gene Symbol

SPRY1

Synonyms

hSPRY1

Gene name

sprouty homolog 1, antagonist of FGF signaling (Drosophila)

Gene Type

protein-coding

Chromosome

4

Genomics Location

4q28.1

Known cancer genes

Yes

Protein products

Protein sprouty homolog 1

Database cross reference

HGNC:11269
MIM:602465
Ensembl:ENSG00000164056
HPRD:06782
RefSeq Genomic nucleotide accession:AC_000047
RefSeq Genomic nucleotide gi:89161206

GO annotation

GO:0001656

metanephros development

GO:0001657

ureteric bud development

GO:0001759

organ induction

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0007173

epidermal growth factor receptor signaling pathway

GO:0007275

multicellular organismal development

GO:0008285

negative regulation of cell proliferation

GO:0009966

regulation of signal transduction

GO:0030027

lamellipodium

GO:0034261

negative regulation of Ras GTPase activity

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

GO:0043407

negative regulation of MAP kinase activity

GO:0046580

negative regulation of Ras protein signal transduction

GO:0051387

negative regulation of nerve growth factor receptor signaling pathway

GO:0070373

negative regulation of ERK1 and ERK2 cascade