Gene basic information
| LiverAtlas Gene ID |
HuLG007066 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
DLC1 |
|
Synonyms |
ARHGAP7|FLJ21120|HP|STARD12|p122NRhoGAP |
|
Gene name |
deleted in liver cancer 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
8 |
|
Genomics Location |
8p22 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ59738, highly similar to Rho-GTPase-activating protein 7 |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:2897
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001725 |
stress fiber |
|
GO:0001843 |
neural tube closure |
|
GO:0003007 |
heart morphogenesis |
|
GO:0005096 |
GTPase activator activity |
|
GO:0005100 |
Rho GTPase activator activity |
|
GO:0005515 |
protein binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005884 |
actin filament |
|
GO:0005901 |
caveola |
|
GO:0005925 |
focal adhesion |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0007165 |
signal transduction |
|
GO:0007202 |
activation of phospholipase C activity |
|
GO:0007264 |
small GTPase mediated signal transduction |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008360 |
regulation of cell shape |
|
GO:0017166 |
vinculin binding |
|
GO:0021575 |
hindbrain morphogenesis |
|
GO:0030036 |
actin cytoskeleton organization |
|
GO:0030336 |
negative regulation of cell migration |
|
GO:0030675 |
Rac GTPase activator activity |
|
GO:0030900 |
forebrain development |
|
GO:0032321 |
positive regulation of Rho GTPase activity |
|
GO:0032869 |
cellular response to insulin stimulus |
|
GO:0032956 |
regulation of actin cytoskeleton organization |
|
GO:0035024 |
negative regulation of Rho protein signal transduction |
|
GO:0035307 |
positive regulation of protein dephosphorylation |
|
GO:0042169 |
SH2 domain binding |
|
GO:0043274 |
phospholipase binding |
|
GO:0043547 |
positive regulation of GTPase activity |
|
GO:0048041 |
focal adhesion assembly |
|
GO:0051056 |
regulation of small GTPase mediated signal transduction |
|
GO:0051497 |
negative regulation of stress fiber assembly |
