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Gene basic information

LiverAtlas Gene ID

HuLG007114

Entrez Gene ID

10454

Official Gene Symbol

TAB1

Synonyms

3'NTab1|MAP3K7IP1|MGC57664

Gene name

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q13.1

Known cancer genes

Yes

Protein products

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, isoform CRA f

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Related liver disease name

Liver fibrosis and liver cirrhosis

Database cross reference

HGNC:18157
MIM:602615
Ensembl:ENSG00000100324
HPRD:04012
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

 

Ontology annotation

GO ID

GO annotation

GO:0000185

activation of MAPKKK activity

GO:0000187

activation of MAPK activity

GO:0001701

in utero embryonic development

GO:0002224

toll-like receptor signaling pathway

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO:0002756

MyD88-independent toll-like receptor signaling pathway

GO:0003007

heart morphogenesis

GO:0003824

catalytic activity

GO:0005515

protein binding

GO:0005829

cytosol

GO:0007179

transforming growth factor beta receptor signaling pathway

GO:0007249

I-kappaB kinase/NF-kappaB cascade

GO:0007254

JNK cascade

GO:0008047

enzyme activator activity

GO:0008063

Toll signaling pathway

GO:0010008

endosome membrane

GO:0019209

kinase activator activity

GO:0030324

lung development

GO:0034130

toll-like receptor 1 signaling pathway

GO:0034134

toll-like receptor 2 signaling pathway

GO:0034138

toll-like receptor 3 signaling pathway

GO:0034142

toll-like receptor 4 signaling pathway

GO:0045087

innate immune response

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051403

stress-activated MAPK cascade