HuLG007483

Entrez Gene ID

10935

Official Gene Symbol

PRDX3

Synonyms

AOPN1|AOP1|MER5|MGC104387|MGC24293|PRO1748|SPN22

Gene name

peroxiredoxin 3

Gene Type

protein-coding

Chromosome

10

Genomics Location

10q25-q26

Known cancer genes

Yes

Protein products

Uncharacterized protein

Thioredoxin-dependent peroxide reductase, mitochondrial

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:9354
MIM:604769
Ensembl:ENSG00000165672
HPRD:05305
RefSeq Genomic nucleotide accession:AC_000053
RefSeq Genomic nucleotide gi:89161186

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0001893

maternal placenta development

GO:0004601

peroxidase activity

GO:0005515

protein binding

GO:0005737

cytoplasm

GO:0005739

mitochondrion

GO:0005769

early endosome

GO:0006979

response to oxidative stress

GO:0007005

mitochondrion organization

GO:0008022

protein C-terminus binding

GO:0008284

positive regulation of cell proliferation

GO:0008385

IkappaB kinase complex

GO:0008785

alkyl hydroperoxide reductase activity

GO:0016491

oxidoreductase activity

GO:0019900

kinase binding

GO:0019901

protein kinase binding

GO:0030099

myeloid cell differentiation

GO:0032496

response to lipopolysaccharide

GO:0033673

negative regulation of kinase activity

GO:0034614

cellular response to reactive oxygen species

GO:0042542

response to hydrogen peroxide

GO:0042744

hydrogen peroxide catabolic process

GO:0042802

identical protein binding

GO:0043027

caspase inhibitor activity

GO:0043066

negative regulation of apoptosis

GO:0043154

negative regulation of caspase activity

GO:0043524

negative regulation of neuron apoptosis

GO:0045454

cell redox homeostasis

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051881

regulation of mitochondrial membrane potential

GO:0051920

peroxiredoxin activity