HuLG007586

Entrez Gene ID

11060

Official Gene Symbol

WWP2

Synonyms

AIP2|WWp2Nlike

Gene name

WW domain containing E3 ubiquitin protein ligase 2

Gene Type

protein-coding

Chromosome

16

Genomics Location

16q22.1

Known cancer genes

Yes

Protein products

cDNA FLJ44359 fis, clone TRACH3007479, highly similar to Homo sapiens Nedd-4-like ubiquitin-protein ligase (WWP2)

NEDD4-like E3 ubiquitin-protein ligase WWP2

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:16804
MIM:602308
Ensembl:ENSG00000198373
HPRD:03812
RefSeq Genomic nucleotide accession:AC_000059
RefSeq Genomic nucleotide gi:89161194

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0000151

ubiquitin ligase complex

GO:0001085

RNA polymerase II transcription factor binding

GO:0004842

ubiquitin-protein ligase activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0006464

protein modification process

GO:0008134

transcription factor binding

GO:0010629

negative regulation of gene expression

GO:0016567

protein ubiquitination

GO:0016874

ligase activity

GO:0016881

acid-amino acid ligase activity

GO:0032410

negative regulation of transporter activity

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO:0043161

proteasomal ubiquitin-dependent protein catabolic process

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

GO:0044419

interspecies interaction between organisms

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0046718

entry of virus into host cell

GO:0051224

negative regulation of protein transport

GO:0070534

protein K63-linked ubiquitination