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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG008342

Entrez Gene ID

23512

Official Gene Symbol

SUZ12

Synonyms

CHET9|JJAZ1|KIAA0160

Gene name

suppressor of zeste 12 homolog (Drosophila)

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q11.2

Known cancer genes

Yes

Protein products

cDNA FLJ76762, highly similar to Homo sapiens suppressor of zeste 12 homolog (Drosophila) (SUZ12), mRNA

Polycomb protein SUZ12

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:17101
MIM:606245
Ensembl:ENSG00000178691
HPRD:06949
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001739

sex chromatin

GO:0003682

chromatin binding

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0006355

regulation of transcription, DNA-dependent

GO:0008270

zinc ion binding

GO:0008284

positive regulation of cell proliferation

GO:0016568

chromatin modification

GO:0016571

histone methylation

GO:0016574

histone ubiquitination

GO:0035064

methylated histone residue binding

GO:0035098

ESC/E(Z) complex

GO:0042054

histone methyltransferase activity

GO:0045596

negative regulation of cell differentiation

GO:0046872

metal ion binding