HuLG008399

Entrez Gene ID

23586

Official Gene Symbol

DDX58

Synonyms

DKFZp434J1111|DKFZp686N19181|FLJ13599|RIGNI

Gene name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Gene Type

protein-coding

Chromosome

9

Genomics Location

9p12

Known cancer genes

Yes

Protein products

Probable ATP-dependent RNA helicase DDX58

DDX58 protein

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Database cross reference

HGNC:19102
MIM:609631
Ensembl:ENSG00000107201
HPRD:13131
RefSeq Genomic nucleotide accession:AC_000052
RefSeq Genomic nucleotide gi:89161215

GO annotation

GO:0000166

nucleotide binding

GO:0002230

positive regulation of defense response to virus by host

GO:0003725

double-stranded RNA binding

GO:0004386

helicase activity

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0008026

ATP-dependent helicase activity

GO:0008270

zinc ion binding

GO:0009597

detection of virus

GO:0016817

hydrolase activity, acting on acid anhydrides

GO:0032480

negative regulation of type I interferon production

GO:0032727

positive regulation of interferon-alpha production

GO:0032728

positive regulation of interferon-beta production

GO:0042993

positive regulation of transcription factor import into nucleus

GO:0045087

innate immune response

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046872

metal ion binding