HuLG008787

Entrez Gene ID

26191

Official Gene Symbol

PTPN22

Synonyms

LYP|LYP1|LYP2|PEP|PTPN8

Gene name

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Gene Type

protein-coding

Chromosome

1

Genomics Location

1p13.2

Known cancer genes

Yes

Protein products

cDNA FLJ55436, highly similar to Tyrosine-protein phosphatase non-receptortype 22 (EC 3.1.3.48)

Tyrosine-protein phosphatase non-receptor type 22

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Biliary cirrhosis

Primary biliary cirrhosis

Database cross reference

HGNC:9652
MIM:600716
Ensembl:ENSG00000134242
HPRD:06100
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

GO annotation

GO:0004725

protein tyrosine phosphatase activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0006470

protein dephosphorylation

GO:0009898

internal side of plasma membrane

GO:0016787

hydrolase activity

GO:0017124

SH3 domain binding

GO:0019900

kinase binding

GO:0030217

T cell differentiation

GO:0032817

regulation of natural killer cell proliferation

GO:0035335

peptidyl-tyrosine dephosphorylation

GO:0035644

phosphoanandamide dephosphorylation

GO:0045088

regulation of innate immune response

GO:0048471

perinuclear region of cytoplasm

GO:0050855

regulation of B cell receptor signaling pathway

GO:0050860

negative regulation of T cell receptor signaling pathway

GO:0050868

negative regulation of T cell activation