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Gene basic information

LiverAtlas Gene ID	HuLG009185
Entrez Gene ID	28996
Official Gene Symbol	HIPK2
Synonyms	DKFZp686K02111\|FLJ23711\|PRO0593
Gene name	homeodomain interacting protein kinase 2
Gene Type	protein-coding
Chromosome	7
Genomics Location	7q32-q34
Known cancer genes	Yes
Protein products	Homeodomain interacting protein kinase 2 Uncharacterized protein Homeodomain-interacting protein kinase 2
Related liver disease name	Hepatocellular carcinoma
Database cross reference	HGNC:14402 MIM:606868 Ensembl:ENSG00000064393 HPRD:06039 RefSeq Genomic nucleotide accession:AC_000050 RefSeq Genomic nucleotide gi:89161211

Liver relevance

HCC significant genes	Yes/No	Yes
	Evidence	EHCO
	Quality score

Ontology annotation

GO ID	GO annotation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000166	nucleotide binding
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0006468	protein phosphorylation
GO:0006915	apoptosis
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007224	smoothened signaling pathway
GO:0007628	adult walking behavior
GO:0008284	positive regulation of cell proliferation
GO:0008629	induction of apoptosis by intracellular signals
GO:0009952	anterior/posterior pattern formation
GO:0016604	nuclear body
GO:0016605	PML body
GO:0019048	virus-host interaction
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0031965	nuclear membrane
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0043388	positive regulation of DNA binding
GO:0043524	negative regulation of neuron apoptosis
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0046332	SMAD binding
GO:0046790	virion binding
GO:0050882	voluntary musculoskeletal movement
GO:0060395	SMAD protein signal transduction