HuLG009230

Entrez Gene ID

29108

Official Gene Symbol

PYCARD

Synonyms

ASC|CARD5|MGC10332|TMS|TMSN1|TMS1

Gene name

PYD and CARD domain containing

Gene Type

protein-coding

Chromosome

16

Genomics Location

16p11.2

Protein products

Apoptosis-associated speck-like protein containing a CARD

Related liver disease name

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:16608
MIM:606838
Ensembl:ENSG00000103490
HPRD:06020
RefSeq Genomic nucleotide accession:AC_000059
RefSeq Genomic nucleotide gi:89161194

GO annotation

GO:0004197

cysteine-type endopeptidase activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005622

intracellular

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006508

proteolysis

GO:0006917

induction of apoptosis

GO:0006919

activation of caspase activity

GO:0006954

inflammatory response

GO:0007165

signal transduction

GO:0008385

IkappaB kinase complex

GO:0008656

caspase activator activity

GO:0032090

Pyrin domain binding

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO:0042803

protein homodimerization activity

GO:0043280

positive regulation of caspase activity

GO:0044444

cytoplasmic part

GO:0050718

positive regulation of interleukin-1 beta secretion

GO:0051092

positive regulation of NF-kappaB transcription factor activity